생약학회지 (Korean Journal of Pharmacognosy)

  • 제39권3호
  • /
  • Pages.265-269
  • /
  • 2008
  • /
  • 0253-3073(pISSN)
  • /
  • 2288-9299(eISSN)
한국생약학회 (The Korean Society of Pharmacognosy)
권호 표지

약용버섯의 생리활성 분석

Analysis of Biological Activities of Medicinal Mushrooms

  • 허현 (동국대학교 생명과학과)
  • Hur, Hyun (Department of Life Science, Dongguk University)
  • 발행 : 2008.09.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

This study was carried out to observe the antioxidative activity, fibrinolytic activity, nitrite savenging ability and adenosine content of three medicinal mushrooms. Among water and ethanol extract of each mushroom, water extract of Inonotus obliquus (Czech) showed the highest antioxidative activity $(57.1{\mu}g/ml)$, nitrite scavenging ability (52.04%), fibrinolytic activity (86.8%) and adenosin content $(94.3{\mu}g/g)$, whereas nitrite scavenging ability of ethanol extract of Phellinus linteus showed higher than that of water extract. Apart from the above statements, water was effective than ethanol as extracting solvent in general. These results suggest that Inonotus obliquus (Czech) showed higher activities such as antioxidative activity, nitrite scavenging ability, fibrinolytic activity and adenosin content and water was effective as solvent except for nitrite scavenging ability.

키워드

참고문헌

  1. An, D.G. (1992) Medicinal mushrooms in Korea. The Korean Journal of Mycology 20: 154-166
  2. Sung, J. M., Yoo, Y. B. and Cha, D. Y. (1998) Mushroom Science. Kyo-Hak Publishing Co., Ltd. Korea. 589-590
  3. Ham, I. H., Jeong, M. Y., Choi, Y. J., Lee, S. D., Sung, H. G., Shim, S. S. and Whang, Y. K. (2002) Physiological activities of Phellinus linteus as ethano-medical preparation Chung-Ang J. Pharm. Sci. 14: 23-27
  4. Chung, K. S. and Kim, S. S. (1994) Effect of Kp, an antitumor protein-polysaccharide from mycelial culture of Phellinus linteus, on the humoral immune response of tumorbearing ICR mice to sheep fed blood cells. Arch. Pharm. Res. 16: 336-338 https://doi.org/10.1007/BF02977527
  5. Ji, J. H., Kim, M. N., Chung, C. K. and Ham, S. S. (2000) Antimutagenic and cytotoxicity effects of Phellinus linteus extracts. J. Korean Soc. Food Sci. Nutr. 29: 322-328
  6. Kier, L. (1961) Triterpenes of Poria obliquus. J. Pharm. Sci. 50: 471-474 https://doi.org/10.1002/jps.2600500605
  7. Kim, D. H., Choi, H. J. and Bae, E. A. (1998) Effects of artificially cultured Phellinus linteus on harmful intestinal bacterial enzymes and rat intestinal $\alpha$-glucosidases. J. Food Hyg. Safty 13: 20-23
  8. Kim, H. M., Han, S. B., Oh, G. T., Kim, Y. H., Hong, D. H., Hong, N. D. and Yoo, I. D. (1996) Stimulation of humoral and cell mediated immunity by polysaccharide from mushroom Phellinus linteus. Int. J. Immunopharmacol. 18: 295-303 https://doi.org/10.1016/0192-0561(96)00028-8
  9. Ikekawa, T., Nakanish, M., Uehara, N., Chihara, G. and Fukuoka, F. (1968) Antitumor action of some basidiomycetes, especially Phellinus. Gann. 59: 1714-1715
  10. Kim, S. Y., Lee, J. U., Kim, K. Y., Park, J. M., Kim, M. O., Lee, T. S. and Lee, J. D. (2004) Phylogenetic relationships between the genus Inontus and its related genera based on the nucleoside sequence of internal transcribed spacers. The Korean Journal of Mycology 32: 152-157 https://doi.org/10.4489/KJM.2004.32.2.152
  11. Terho, M. and Hallaksela, A-M. (2005) Potential hazard characteristics of Tilia, Betula, and Acer trees removed in the Helsinki city area during 2001-2003. Urban Forestry & Urban Greening 3: 113-120 https://doi.org/10.1016/j.ufug.2004.07.002
  12. Shivrina, A. N. (1967) Chemical characteristics of compounds extracted from Inonotus obliquus. Chem. Abstr. 66: 17271-17279
  13. Kahols K., Kangas L. and Hitunen R. (1987) Antitumor activity of some compounds and fractions from an n-hexane extract of Inonotus obliquus in vitro. Acta. Pharm. Fennica. 96: 33-40
  14. Kahols K., Kangas L. and Hitunen R. (1989) Ergosterol peroxide, an active compounds from Inonotus obliquus. Planta Med. 55: 389-390 https://doi.org/10.1055/s-2006-962036
  15. Hwang, Y. I., Rho, K. W. and Kim, S. H. (2003) Effects of Inonotus obliquus extracts of proliferation and caspase-3 activity in human castro-intestinal cancer cell lines. Kor. J. Nutr. 36: 18-23
  16. Chung, Y. S. (2002) A study of disease treatment by Inonotus mushroom. Ph.D thesis, Evangel Christian Univ. of America
  17. Williams, W. B., Cuvelier, M. E. and Berset, C. (1995) Use of a free radical method to evaluate antioxidant activity. LWT. 28: 25-30 https://doi.org/10.1016/S0023-6438(95)80008-5
  18. Grayand, J. and Dugan, L. R. (1975) Inhibition of N-nitrosoamine formation in model food system. J. Kor. Soc. Food Sci. 40: 981-985 https://doi.org/10.1111/j.1365-2621.1975.tb02248.x
  19. Yang, E. I. (2005) Physiological functions of Chungkook-jang and viscous substance. master thesis, Chonbuk national university, Jeonju, Korea
  20. Herting, M. C. L., Feskens, E. J. M., Hoffman, P, C. H., Katan, M. B. and Kromhout, D. (1993) Dietart antioxidant flavonoids and risk of coronary heart disease : the zutphen Elderly study. Lancer 342: 1007-1011 https://doi.org/10.1016/0140-6736(93)92876-U
  21. Torel, J., Gillard, J. and Gillard, P. (1986) Antioxidant activity of flavonoids and reactivity with peroxy radical. Phytochemistry 25: 383-385 https://doi.org/10.1016/S0031-9422(00)85485-0
  22. Lee, S. K. (1997) Evaluation of cancer chemopreventive activity mediated by antioxidants and modulators of tumor promotion. Ph D thesis. University of Illinois at Chicaco. pp. 52-54
  23. Peter F. S. (1975) The toxicology of nitrate, nitrate and Nnitroso compounds. J. Sci. Food. Agric. 52: 1761-1764
  24. Marks, D., Marks, A. and Smith, C. (1996) Basic medical biochemistry. Williams and Wikins, Baltimore. p 157
  25. Chung, K. H. and Kim, D. S. (1992) Fibrinolytic and coagulation activities of Korean snake venoms. Korean Biochem. J. 25: 696-701
  26. Park, Y. D., Kim, J. W., Min, B. G., Seo, J. W. and Jeong, J. M. (1998) Rapid purification and biochemical characteristics of Lumbrokinase III from earthworm for use as a fibrinolytic agent. Biotechnol. Lett. 20: 169-172 https://doi.org/10.1023/A:1005384625974
  27. Kim, J. H., Yoo, K .H., Seok, S. J. and Kim, Y.S. (2005) Screening of fibrinolytic activities of extracts from wild mushroom. Journal of Mycology 33: 18-21 https://doi.org/10.4489/KJM.2005.33.1.018
  28. Park, J. S., Hyun, K. W., Seo, S. B., Cho, S. M., Yoo, C. H. and Lee, J. S. (2003) Detection of platelet aggregation inhibitors and fibrinolytic substances from mushrooms. The Korean Journal of Mycology 31: 114-116 https://doi.org/10.4489/KJM.2003.31.2.114
  29. Mizuno, T. (1994) Food Function and Medicinal Effects of Mushroom Fungi. pp 1-170. Laboratory of Biochemistry. Faculty of Agriculture, Shizuoka University, Shizuoka