The Journal of Korean Medicine (대한한의학회지)
- Volume 29 Issue 4
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- Pages.133-145
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- 2008
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- 1010-0695(pISSN)
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- 2288-3339(eISSN)
The Effects of Hirudo on Streptozotocin-induced Diabetic Nephropathic Rats
수질(水蛭)이 Streptozotocin으로 유발된 Rat의 당뇨병성(糖尿病性) 신증(腎症)에 미치는 영향(影響)
- Seo, Su-Hwan (Dept. of Internal Medicine. College of Oriental Medicine, Dongshin University) ;
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Kim, Yong-Seong
(Dept. of Internal Medicine. College of Oriental Medicine, Dongshin University) ;
- Han, Yang-Hee (Dept. of Internal Medicine. College of Oriental Medicine, Dongshin University)
- Published : 2008.09.30
Abstract
Objectives: The aim of present study was to investigate recovery effects of Hirudo, which has been used clinically in diabetes therapy. Methods: We established three groups: normal, control, Hirudo, and assigned 6 rats to each group. The normal group was not treated by any process and fed by normal saline. The control & Hirudo groups were administered streptozotocin (STZ) to induce diabetes. Hirudo extract was orally administered to the Hirudo group for 10 days. After 8 weeks, the rats were sacrificed and their body weight, 24hrs urinary protein excretion, glucose, albumin, BUN, creatinine, total-cholesterol, LDL-cholesterol, triglyceride in blood, and level of glycation end-product (AGE) and transforming growth factor (TGF-