Tuberculosis and Respiratory Diseases

The Korean Academy of Tuberculosis and Respiratory Diseases (대한결핵및호흡기학회)
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A Case of the Minimal Change Nephropathy Associated with Small Cell Lung Cancer

소세포폐암에 동반된 미세변화 신증후군 1예

  • Ko, Kwang Il (Department of Internal Medicine, National Health Insurance Corporation Ilsan Hospital) ;
  • Song, Min Keun (Department of Internal Medicine, National Health Insurance Corporation Ilsan Hospital) ;
  • Shin, Dong Yeob (Department of Internal Medicine, National Health Insurance Corporation Ilsan Hospital) ;
  • Kim, Dong Hyun (Department of Internal Medicine, National Health Insurance Corporation Ilsan Hospital) ;
  • Kim, Chan Ho (Department of Internal Medicine, National Health Insurance Corporation Ilsan Hospital) ;
  • Han, Chang Hoon (Department of Internal Medicine, National Health Insurance Corporation Ilsan Hospital) ;
  • Lee, Sun Min (Department of Internal Medicine, National Health Insurance Corporation Ilsan Hospital) ;
  • Choi, Yoon Jung (Department of Pathology, National Health Insurance Corporation Ilsan Hospital) ;
  • Kim, Chong Ju (Department of Internal Medicine, National Health Insurance Corporation Ilsan Hospital)
  • 고광일 (국민건강보험공단 일산병원 내과) ;
  • 송민근 (국민건강보험공단 일산병원 내과) ;
  • 신동엽 (국민건강보험공단 일산병원 내과) ;
  • 김동현 (국민건강보험공단 일산병원 내과) ;
  • 김찬호 (국민건강보험공단 일산병원 내과) ;
  • 한창훈 (국민건강보험공단 일산병원 내과) ;
  • 이선민 (국민건강보험공단 일산병원 내과) ;
  • 최윤정 (국민건강보험공단 일산병원 병리과) ;
  • 김정주 (국민건강보험공단 일산병원 내과)
  • Received : 2008.05.09
  • Accepted : 2008.06.17
  • Published : 2008.07.30
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Abstract

Nephrotic syndrome is a relatively rare complication of malignancy. A few cases of nephrotic syndrome accompanying Hodgkin's disease, non-Hodgkin lymphoma, leukemia and other malignancies have been reported since the first case of the nephrotic syndrome associated with extrarenal malignancy was reported in 1922. Hodgkin's disease and solid tumors are known to be the most common malignancies accompanying nephrotic syndrome. The pathologic findings of kidney in patients with Hodgkin's disease commonly show minimal change nephropathy. Membranous glomerulonephropathy is the most common pathologic feature in patients with solid tumors. Although membranous glomerulonephropathy related to small cell lung cancer has rarely been reported in Korea, minimal change nephropathy accompanying small cell lung cancer has never been reported. We present here a case of a 70 year-old male with minimal change nephropathy that was related to small cell lung cancer. We detected small cell lung cancer during the diagnosis work-up of nephrotic syndrome. We suggest that nephrotic syndrome can be a manifestation of underlying malignancy.

본 증례는 소세포폐암에 동반된 미세변화 신증후군에 대한 국내 첫 번째 보고이며, 흉막여출액에 의한 호흡곤란과 말초부종 등 미세변화 신증훈군의 증상 발현에 의해 내원하여 잠재암이 발견된 경우이다. 본 증례를 통하여 성인의 경우 막성신병증 뿐만 아니라 미세변화 신증후군이라도 초기진단 시 원인질환으로 종양의 가능성을 고려해야 한다는 것을 경험하게 되었다.

Keywords

References

  1. Galloway J. Remarks on Hodgkin's disease. Br Med J 1922;2:1201-4. https://doi.org/10.1136/bmj.2.3234.1201
  2. Lee JC, Yamauchi H, Hopper J Jr. The association of cancer and the nephrotic syndrome. Ann Intern Med 1966;64:41-51. https://doi.org/10.7326/0003-4819-64-1-41
  3. Plager J, Stutzman L. Acute nephrotic syndrome as a manifestation of active Hodgkin's Disease. Report of four cases and review of the literature. Am J Med 1971;50:56-66. https://doi.org/10.1016/0002-9343(71)90205-1
  4. Kiely JM, Wagoner RD, Holley KE. Renal complications of lymphoma. Ann Intern Med 1969;71:1159-75. https://doi.org/10.7326/0003-4819-71-6-1159
  5. Gagliano RG, Costanzi JJ, Beathard GA, Sarles HE, Bell JD. The nephrotic syndrome associated with neoplasia: an unusual paraneoplastic syndrome. Report of a case and review of the literature. Am J Med 1976;60:1026-31. https://doi.org/10.1016/0002-9343(76)90575-1
  6. Meyrier A, Delahousse M, Callard P, Rainfray M. Minimal change nephrotic syndrome revealing solid tumors. Nephron 1992;61:220-3. https://doi.org/10.1159/000186877
  7. Moon HL, Kim YS, Yoon YS, Lee KS, Bang BK, Kim DJ, et al. A case of membranous nephropathy associated with small cell lung cancer. J Korean Med Assoc 1990;33:1038-42.
  8. Yang CW, Bae SH, Jin JY, Kim KH, Kim SY, Bang BK, et al. A case of the membranous nephropathy as a prodrome to small cell lung cancer. Korean J Nephrol 1993;12:115-8.
  9. Ghosh L, Muehrcke RC. Nephrotic syndrome: a prodrome to lymphoma. Ann Intern Med 1970;72:379-82. https://doi.org/10.7326/0003-4819-72-3-379
  10. da Costa CR, Dupont E, Hamers R, Hooghe R, Dupuis E, Potvliege R. Nephrotic syndrome in bronchogenic carcinoma: report of two cases with immunochemical studies. Clin Nephrol 1974;2:245-51.
  11. Yamauchi H, Linsey MS, Biava CG, Hopper J Jr. Cure of membranous nephropathy after resection of carcinoma. Arch Intern Med 1985;145:2061-3. https://doi.org/10.1001/archinte.145.11.2061
  12. Robinson WL, Mitas JA 2nd, Haerr RW, Cohen IM. Remission and exacerbation of tumor-related nephrotic syndrome with treatment of the neoplasm. Cancer 1984;54:1082-4. https://doi.org/10.1002/1097-0142(19840915)54:6<1082::AID-CNCR2820540625>3.0.CO;2-3
  13. Couser WG, Wagonfeld JB, Spargo BH, Lewis EJ. Glomerular deposition of tumor antigen in membranous nephropathy associated with colonic carcinoma. Am J Med 1974;57:962-70. https://doi.org/10.1016/0002-9343(74)90176-4
  14. Costanza ME, Pinn V, Schwartz RS, Nathanson L. Carcinoembryonic antigen-antibody complexes in a patient with colonic carcinoma and nephrotic syndrome. N Engl J Med 1973;289:520-2. https://doi.org/10.1056/NEJM197309062891007
  15. Lewis MG, Loughridge LW, Phillips TM. Immunological studies in nephrotic syndrome associated with extrarenal malignant disease. Lancet 1971;2:134-5.