Bilateral Pulmonary Infiltrate with Milky BAL Fluid

우유빛 기관지 세척액 소견을 보인 양측성 폐침윤

  • Yoon, Gi Chol (Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Korea University College of Medicine) ;
  • Moon, Jae Young (Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Korea University College of Medicine) ;
  • Kim, Hye Ok (Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Korea University College of Medicine) ;
  • Kim, Jung Ha (Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Korea University College of Medicine) ;
  • Ha, Eun Sil (Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Korea University College of Medicine) ;
  • Lee, Kyung Ju (Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Korea University College of Medicine) ;
  • Lee, Eun Joo (Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Korea University College of Medicine) ;
  • Hur, Gyu Young (Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Korea University College of Medicine) ;
  • Kang, Eun Hae (Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Korea University College of Medicine) ;
  • Jung, Ki Hwan (Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Korea University College of Medicine) ;
  • Lee, Sung Yong (Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Korea University College of Medicine) ;
  • Kim, Je Hyeong (Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Korea University College of Medicine) ;
  • Lee, Sang Yeub (Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Korea University College of Medicine) ;
  • Shin, Chol (Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Korea University College of Medicine) ;
  • Shim, Jae Jeong (Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Korea University College of Medicine) ;
  • In, Kwang Ho (Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Korea University College of Medicine) ;
  • Kang, Kyung Ho (Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Korea University College of Medicine) ;
  • Yoo, Se Hwa (Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Korea University College of Medicine)
  • 윤기철 (고려대학교 의과대학 내과학교실) ;
  • 문재영 (고려대학교 의과대학 내과학교실) ;
  • 김혜옥 (고려대학교 의과대학 내과학교실) ;
  • 김정하 (고려대학교 의과대학 내과학교실) ;
  • 하은실 (고려대학교 의과대학 내과학교실) ;
  • 이경주 (고려대학교 의과대학 내과학교실) ;
  • 이은주 (고려대학교 의과대학 내과학교실) ;
  • 허규영 (고려대학교 의과대학 내과학교실) ;
  • 강은해 (고려대학교 의과대학 내과학교실) ;
  • 정기환 (고려대학교 의과대학 내과학교실) ;
  • 이승룡 (고려대학교 의과대학 내과학교실) ;
  • 김제형 (고려대학교 의과대학 내과학교실) ;
  • 이상엽 (고려대학교 의과대학 내과학교실) ;
  • 신철 (고려대학교 의과대학 내과학교실) ;
  • 심재정 (고려대학교 의과대학 내과학교실) ;
  • 인광호 (고려대학교 의과대학 내과학교실) ;
  • 강경호 (고려대학교 의과대학 내과학교실) ;
  • 유세화 (고려대학교 의과대학 내과학교실)
  • Received : 2008.04.29
  • Accepted : 2008.08.25
  • Published : 2008.09.30

Abstract

Exogenous lipoid pneumonia is an uncommon disease that's caused by aspirating lipid formulations. Squalene, obtained from shark liver oil, is one of the causative agent and this is commonly used by some Koreans as a health promoting medication. We report here on a case of exogenous lipoid pneumonia that developed after ingestion of squalene capsules. The case showed milky BAL fluid and multiple pulmonary consolidations.

외인성 지방성 폐렴은 자세한 병력 청취 없이는 의심하기 힘든 비교적 드문 질환이다. 저자들은 비특이적인 임상 증상과 방사선 소견을 보인 환자에서 스쿠알렌을 섭취한 과거력에 주목하였으며 외인성 지방성 폐렴을 의심 하에 기관지폐세척술 및 폐 생검을 통하여 확진하였다.

Keywords

References

  1. Laughlen GF. Studies on pneumonia following naso-pharyngeal injections of oil. Am J Pathol 1925;1:407-14.
  2. Asnis DS, Saltzman HP, Melchert A. Shark oil pneumonia. An overlooked entity. Chest 1993;103:976-7. https://doi.org/10.1378/chest.103.3.976
  3. Camus P, Bonniaud P, Fanton A, Camus C, Baudaun N, Foucher P. Drug-induced and iatrogenic infiltrative lung disease. Clin Chest Med 2004;25:479-519, vi. https://doi.org/10.1016/j.ccm.2004.05.006
  4. Gondouin A, Manzoni P, Ranfaing E, Brun J, Cadranel J, Sadoun D, et al. Exogenous lipid pneumonia: a retrospective multicentre study of 44 cases in France. Eur Respir J 1996;9:1463-9. https://doi.org/10.1183/09031936.96.09071463
  5. Robinson GV, Kanji H, Davies RJ, Gleeson FV. Selective pulmonary fat aspiration complicating oesophageal achalasia. Thorax 2004;59:180. https://doi.org/10.1136/thx.2003.017814
  6. de Albuquerque Filho AP. Exogenous lipoid pneumonia: importance of clinical history to the diagnosis. J Bras Pneumol 2006;32:596-8. https://doi.org/10.1590/S1806-37132006000600020
  7. Ohwada A, Yoshioka Y, Shimanuki Y, Mitani K, Kumasaka T, Dambara T, et al. Exogenous lipoid pneumonia following ingestion of liquid paraffin. Intern Med 2002;41:483-6. https://doi.org/10.2169/internalmedicine.41.483
  8. Park HP, Kwon KY, Choi WI. Lipoid pneumonia in Korea: a case report and review of the literature of Korean cases. Respir Med Extra 2007;3:39-43. https://doi.org/10.1016/j.rmedx.2007.01.007
  9. Choi HS, Kwag HJ, Chae SW, Lim SY, Lim SY. Severe exogenous lipoid pneumonia following ingestion of large dose squalene: successful treatment with steroid. Tuberc Respir Dis 2006;60:235-8. https://doi.org/10.4046/trd.2006.60.2.235
  10. Ioachimescu OC, Kavuru MS. Pulmonary alveolar proteinosis. Chron Respir Dis 2006;3:149-59. https://doi.org/10.1191/1479972306cd101rs
  11. Simmons A, Rouf E, Whittle J. Not your typical pneumonia: a case of exogenous lipoid pneumonia. J Gen Intern Med 2007;22:1613-6. https://doi.org/10.1007/s11606-007-0280-7
  12. Rossi SE, Erasmus JJ, Volpacchio M, Franquet T, Castiglioni T, McAdams HP. "Crazy-paving" pattern at thin-section CT of the lungs: radiologic-pathologic overview. Radiographics 2003;23:1509-19. https://doi.org/10.1148/rg.236035101