Tuberculosis and Respiratory Diseases

The Korean Academy of Tuberculosis and Respiratory Diseases (대한결핵및호흡기학회)
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Use of Molecular Identification Analysis in a Case of Intra-familial Transmission of Tuberculosis

결핵균의 유전자 분석법으로 증명된 가족 내 결핵 전파 1예

  • Park, Eui Ju (Division of Respiratory and Allergy Medicine, Department of Internal Medicine, School of Medicine, Soonchunhyang University) ;
  • Kim, Yang-Ki (Division of Respiratory and Allergy Medicine, Department of Internal Medicine, School of Medicine, Soonchunhyang University) ;
  • Bok, Jin Hyun (Division of Respiratory and Allergy Medicine, Department of Internal Medicine, School of Medicine, Soonchunhyang University) ;
  • Lee, Young Mok (Division of Respiratory and Allergy Medicine, Department of Internal Medicine, School of Medicine, Soonchunhyang University) ;
  • Kim, Ki-Up (Division of Respiratory and Allergy Medicine, Department of Internal Medicine, School of Medicine, Soonchunhyang University) ;
  • Uh, Soo-taek (Division of Respiratory and Allergy Medicine, Department of Internal Medicine, School of Medicine, Soonchunhyang University) ;
  • Park, Young-Kil (Korean Institute of Tuberculosis, Korean National Tuberculosis Association)
  • 박의주 (순천향대학교 의과대학 내과학교실, 호흡기알레르기내과) ;
  • 김양기 (순천향대학교 의과대학 내과학교실, 호흡기알레르기내과) ;
  • 복진현 (순천향대학교 의과대학 내과학교실, 호흡기알레르기내과) ;
  • 이영목 (순천향대학교 의과대학 내과학교실, 호흡기알레르기내과) ;
  • 김기업 (순천향대학교 의과대학 내과학교실, 호흡기알레르기내과) ;
  • 어수택 (순천향대학교 의과대학 내과학교실, 호흡기알레르기내과) ;
  • 박영길 (대한결핵협회 결핵연구원)
  • Received : 2008.09.08
  • Accepted : 2008.10.14
  • Published : 2008.12.30
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Abstract

결핵균은 공기를 매개로 전파되고 결핵균에 노출된 시간과 최초의 노출 정도가 전파의 위험을 증가 시키는 중요한 인자로 알려져 있다. 활동성 폐결핵 환자와 함께 생활하는 가족 내에서 감염이 현저히 증가하는데 이는 결핵균에 노출되는 기회 및 시간이 증가하기 때문이다. 하지만 고식적인 접촉자 조사만으로는 흔히 결핵 발생률을 과소평가할 수 있기 때문에 접촉자 조사와 결핵균의 유전형 조사를 병행하는 것이 감염의 위험이 높은 집단을 선별해내고 발생빈도 및 전염경로를 밝히는 데 보다 효과적인 것으로 보고되고 있다. 이에 접촉자 조사와 결핵균의 유전형 조사를 통해 가족 내 결핵균 전파를 증명한 1예를 보고하는 바이다.

Keywords

References

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