Applied Chemistry for Engineering (공업화학)

The Korean Society of Industrial and Engineering Chemistry (한국공업화학회)
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Nano-capsulation of L-Ascorbic Acid in Nonaqueous System

L-Ascorbic Acid의 비수계 나노 캡슐화

  • Hong, Joo-Hee (Department of Chemical & Biochemical Engineering, Dongguk University) ;
  • Song, Ki-Se (Department of Chemical & Biochemical Engineering, Dongguk University) ;
  • Kim, Kyoung-Jun (Department of Chemical & Biochemical Engineering, Dongguk University) ;
  • Lee, Chae-Seong (Department of Chemical & Biochemical Engineering, Dongguk University) ;
  • An, Byeong-Min (Department of Chemical & Biochemical Engineering, Dongguk University) ;
  • Kim, Byoung-Sik (Department of Chemical & Biochemical Engineering, Dongguk University)
  • 홍주희 (동국대학교 화공.생물공학과) ;
  • 송기세 (동국대학교 화공.생물공학과) ;
  • 김경준 (동국대학교 화공.생물공학과) ;
  • 이채성 (동국대학교 화공.생물공학과) ;
  • 안병민 (동국대학교 화공.생물공학과) ;
  • 김병식 (동국대학교 화공.생물공학과)
  • Received : 2008.06.30
  • Accepted : 2008.10.16
  • Published : 2008.12.10
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Abstract

In this work, the basic research for nano-capsulation of L-ascorbic acid (Vitamin C) in nonaqueous system was carried out. 500 nm-sized nano-capsules were prepared in nonaqueous system, and the emulsified capsule had mean size of 410 nm. The stability test on the temperature and the storage periods was performed at 4, 20, and $30^{\circ}C$ for 30 days. After 5 days, L-ascorbic acid was extricated 5.1, 9.3, and 12.5% at each temperature, but only 1~2 % was extricated after the time span. Likewise, the results of the skin susceptibility on women and men, each 10 persons, revealed that the very thin allergy was shown from only a woman after 2 days, but it was not shown from the others.

본 연구에서는 L-아스코르빈산(L-ascorbic acid: Vitamin C)을 점성이 낮은 비수계 오일상에서의 나노 캡슐화(nano-capsulation)에 대한 기초 연구가 수행되었다. 비수계에서 제조된 나노 캡슐체들은 500 nm 이하 크기를 나타냈으며 유화물형태에서의 평균 입자 크기는 410 nm로 나타났다. 온도와 저장 기간에 대한 안정도는 4, 20, $30^{\circ}C$ 온도에서 30일간 저장했을 때 최초 5일 후에는 5.1, 9.3, 12.5%의 L-아스코르빈산이 캡슐체로부터 유리되어 나왔으나 이후 기간 동안에는 약 1~2% 정도가 유리되어 나왔다. 또한, 남녀 각각 10명의 대상인원에 대한 피부 자극도는 1명만이 2일 후에 아주 미세한 피부 자극이 나타났으며 다른 인원에게서는 무자극성을 나타내었다.

Keywords

References

  1. F. Shahidi and X. Q. Han, Critical Reviews in Food Science and Nutrition, 33, 501 (1993). https://doi.org/10.1080/10408399309527645
  2. U. R. Pothakamury and G. V. Barbosa-Canovas, Trends in Food Science & Technology, 6, 397 (1995). https://doi.org/10.1016/S0924-2244(00)89218-3
  3. J. D. Dziezak, Food Technology, 52, 136 (1998).
  4. D. E. Pszczola, Food Technology, 52, 70 (1998).
  5. S. K. Kanawjia, V. Pathania, and S. Singh. Indian Dairyman, 44, 280 (1992).
  6. G. O. Fanger, Microcapsulation processes and application, Plenum press, NY, (1974).
  7. P. B. Deasy, Microencapsulation and related drug processes, Marcel Dekker. Inc., NY, (1984).
  8. USP 2, 556, 410 (1951).
  9. B. Y. Ahn, J. H. Kim, S. I. Seok, S. Y. Ko, and H. K. Chang, J. Korean Ind. Eng. Chem., 13, 672 (2002).
  10. L. J. Machlin, Handbook of Vitamins, 2nd Ed, Marcel Dekker, Inc., NY, (1991).
  11. T. Doba, G. W. Burton, and K. U. Ingold, Biochim. Biophys. Acta, 835, 298 (1985). https://doi.org/10.1016/0005-2760(85)90285-1
  12. A. Bossi, S. A. Piletsky, E. V. Piletska, P. G. Righetti, and A. Turner, Anal Chem., 2, 4296 (2007).
  13. L. Yamamoto, A. Tai, Y. Fujinami, K. Sasaki, K. Okazaki, and S. J. Okazaki, Med. Chem., 45, 462 (2002). https://doi.org/10.1021/jm010379f
  14. H. Tsuchiya and C. J. Bates, J. Nurt. Biochem., 9, 402 (1998). https://doi.org/10.1016/S0955-2863(98)00039-4
  15. Y. Horino, S. Takahashi, T. Miura, and Y. Takahashi, Life Science, 71, 3031 (2002). https://doi.org/10.1016/S0024-3205(02)02142-2
  16. L. S. Goodman and A. Gilman., As Bases Farmacologicas da Terapeutica, 9th Ed., McGraw Hill, (1996).
  17. I. M. J. Hamilton, W. S. Gilmore, I. F. F. Benzie, C. W. Mulholland, and J. J. Strain, British Journal of Nutrition, 84, 261 (2000). https://doi.org/10.1017/S0007114500001537
  18. USP 5, 286, 495 (1994).