우리나라 성인 남성에서 흡연량과 공복혈당장애 또는 제2형 당뇨병 발생과의 연관성

The Effect of Smoking Status upon Occurrence of Impaired Fasting Glucose or Type 2 Diabetes in Korean Men

  • 박창해 (인하대학교 의과대학 가정의학과) ;
  • 가혁 (인천 은혜병원 노인의학 연구소) ;
  • 임종환 (인하대학교 의과대학 산업의학과) ;
  • 곽승민 (인하대학교 의과대학 호흡기내과) ;
  • 김환철 (인하대학교 의과대학 산업의학과) ;
  • 최지호 (인하대학교 의과대학 가정의학과)
  • Park, Chang-Hae (Department of Family Medicine, Inha University College of Medicine, Institute of Geriatric Medicine) ;
  • Ga, Hyuk (Eun-Hye Hospital) ;
  • Lee, Jong-Han (Department of Occupational Medicine, Inha University College of Medicine) ;
  • Kwak, Seung-Min (Department of Internal Medicine, Inha University College of Medicine) ;
  • Kim, Hwan-Cheol (Department of Occupational Medicine, Inha University College of Medicine) ;
  • Choi, Ji-Ho (Department of Family Medicine, Inha University College of Medicine, Institute of Geriatric Medicine)
  • 발행 : 2008.07.31

초록

Objectives: To investigate whether smoking and the smoking status are predictors of the incident impaired fasting glucose (IFG) or type 2 diabetes in Korean men. Methods: A cohort of 1,717 Korean men without IFG or diabetes, who underwent annual periodic health examinations for 4 years (2002-2006), were retrospectively investigated. IFG and diabetes were defined as a serum fasting glucose concentration of 100-125 mg/dL and more than 126 mg/dL, respectively. Cox's proportional hazards model was used to evaluate the association between smoking and development of IFG or type 2 diabetes. Results: A total of 558 cases (32.5%) of incident IFG and 50 cases (2.9%) of diabetes occurred. After controlling for the potential predictors of diabetes, the relative risk for IFG, compared with the never smokers, was 1.02 (95% CI=0.88 to 1.19) for the ever-smokers, 0.96 (95% CI=0.79-1.16) for those who smoked 1-9 cigarettes/d, 1.15 (95% CI=1.01 to 1.30) for those who smoked 10-19 cigarettes/d, and 1.31 (95% CI=1.10 to 1.57) for those who smoked 20 or more cigarettes/d (the P value for the current smokers was only p<0.002). The respective multivariate adjusted relative risks for type 2 diabetes, compared with the never-smokers, were 1.07 (95% CI=0.64 to 1.92), 1.47 (95% CI=0.71 to 3.04), 1.84 (95% CI=0.92-3.04), and 1.87 (95% CI=1.13-3.67), respectively (the P value for the current smokers was only p=0.004). Conclusions: The smoking status and the number of cigarettes smoked daily are associated with an increased risk for developing IFG or type 2 diabetes in Korean men.

키워드

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