Journal of Preventive Medicine and Public Health

  • 제41권4호
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  • Pages.249-254
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  • 2008
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  • 1975-8375(pISSN)
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  • 2233-4521(eISSN)
대한예방의학회 (The Korean Society for Preventive Medicine)
권호 표지

우리나라 성인 남성에서 흡연량과 공복혈당장애 또는 제2형 당뇨병 발생과의 연관성

The Effect of Smoking Status upon Occurrence of Impaired Fasting Glucose or Type 2 Diabetes in Korean Men

  • 박창해 (인하대학교 의과대학 가정의학과) ;
  • 가혁 (인천 은혜병원 노인의학 연구소) ;
  • 임종환 (인하대학교 의과대학 산업의학과) ;
  • 곽승민 (인하대학교 의과대학 호흡기내과) ;
  • 김환철 (인하대학교 의과대학 산업의학과) ;
  • 최지호 (인하대학교 의과대학 가정의학과)
  • Park, Chang-Hae (Department of Family Medicine, Inha University College of Medicine, Institute of Geriatric Medicine) ;
  • Ga, Hyuk (Eun-Hye Hospital) ;
  • Lee, Jong-Han (Department of Occupational Medicine, Inha University College of Medicine) ;
  • Kwak, Seung-Min (Department of Internal Medicine, Inha University College of Medicine) ;
  • Kim, Hwan-Cheol (Department of Occupational Medicine, Inha University College of Medicine) ;
  • Choi, Ji-Ho (Department of Family Medicine, Inha University College of Medicine, Institute of Geriatric Medicine)
  • 발행 : 2008.07.31
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초록

Objectives: To investigate whether smoking and the smoking status are predictors of the incident impaired fasting glucose (IFG) or type 2 diabetes in Korean men. Methods: A cohort of 1,717 Korean men without IFG or diabetes, who underwent annual periodic health examinations for 4 years (2002-2006), were retrospectively investigated. IFG and diabetes were defined as a serum fasting glucose concentration of 100-125 mg/dL and more than 126 mg/dL, respectively. Cox's proportional hazards model was used to evaluate the association between smoking and development of IFG or type 2 diabetes. Results: A total of 558 cases (32.5%) of incident IFG and 50 cases (2.9%) of diabetes occurred. After controlling for the potential predictors of diabetes, the relative risk for IFG, compared with the never smokers, was 1.02 (95% CI=0.88 to 1.19) for the ever-smokers, 0.96 (95% CI=0.79-1.16) for those who smoked 1-9 cigarettes/d, 1.15 (95% CI=1.01 to 1.30) for those who smoked 10-19 cigarettes/d, and 1.31 (95% CI=1.10 to 1.57) for those who smoked 20 or more cigarettes/d (the P value for the current smokers was only p<0.002). The respective multivariate adjusted relative risks for type 2 diabetes, compared with the never-smokers, were 1.07 (95% CI=0.64 to 1.92), 1.47 (95% CI=0.71 to 3.04), 1.84 (95% CI=0.92-3.04), and 1.87 (95% CI=1.13-3.67), respectively (the P value for the current smokers was only p=0.004). Conclusions: The smoking status and the number of cigarettes smoked daily are associated with an increased risk for developing IFG or type 2 diabetes in Korean men.

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참고문헌

  1. Zimmet P. Globalization, coca-colonization and the chronic disease epidemic: Can the Doomsday scenario be averted? J Intern Med 2000; 247(3): 301-310 https://doi.org/10.1046/j.1365-2796.2000.00625.x
  2. King H, Aubert RE, Herman WH. Global burden of diabetes, 1995-2025: Prevalence, numerical estimates, and projections. Diabetes Care 1998; 21(9): 1414-1431 https://doi.org/10.2337/diacare.21.9.1414
  3. World Health Organization. WHO diabetes programme. [cited 2007 Aug 5]; Available from: URL: http://www.who.int/diabetes/en
  4. King H, Rewers M. Global estimates for prevalence of diabetes mellitus and impaired glucose tolerance in adults. WHO Ad Hoc Diabetes Reporting Group. Diabetes Care 1993; 16(1): 157-177 https://doi.org/10.2337/diacare.16.1.157
  5. Park SW, Kim DJ, Min KW, Baik SH, Choi KM, Park IB, et al. Current status of diabetes management in Korea using national health insurance database. J Korean Diabetes Assoc 2007; 31(4): 362-367. (Korean) https://doi.org/10.4093/jkda.2007.31.4.362
  6. Colditz GA, Willett WC, Rotnitzky A, Manson JE. Weight gain as a risk factor for clinical diabetes mellitus in women. Ann Intern Med 1995; 122(7): 481-486 https://doi.org/10.7326/0003-4819-122-7-199504010-00001
  7. Feskens EJ, Kromhout D. Cardiovascular risk factors and the 25-year incidence of diabetes mellitus in middle-aged men. The Zutphen Study. Am J Epidemiol 1989; 130(6): 1101-1108 https://doi.org/10.1093/oxfordjournals.aje.a115437
  8. Helmrich SP, Ragland DR, Leung RW, Paffenbarger RS Jr. Physical activity and reduced occurrence of non-insulin-dependent diabetes mellitus. N Engl J Med 1991; 325(3): 147-152 https://doi.org/10.1056/NEJM199107183250302
  9. Kim DH, Ahn YO, Park SW, Choi MG, Kim DS, Lee MS, et al. Incidence and risk factors for diabetes mellitus in Korean middle-aged men: Seoul cohort DM follow-up study. Korean J Prev Med 1999; 32(4): 526-537. (Korean)
  10. Kim JS, Kim YJ, Park SI, Hong YP. Mean fasting blood glucose level and an estimated prevalence of diabetes mellitus among a representative adult Korean population. Korean J Prev Med 1993; 26(3): 311-320. (Korean)
  11. Rimm EB, Chan J, Stampfer MJ, Colditz GA, Willett WC. Prospective study of cigarette smoking, alcohol use, and the risk of diabetes in men. BMJ 1995; 310(6979): 555-559 https://doi.org/10.1136/bmj.310.6979.555
  12. Kawakami N, Takatsuka N, Shimizu H, Ishibashi H. Effects of smoking on the incidence of non-insulin-dependent diabetes mellitus: Replication and extension in a Japanese cohort of male employees. Am J Epidemiol 1997; 145(2): 103-109 https://doi.org/10.1093/oxfordjournals.aje.a009080
  13. Uchimoto S, Tsumura K, Hayashi T, Suematsu C, Endo G, Fujii S, et al. Impact of cigarette smoking on the incidence of Type 2 diabetes mellitus in middle-aged Japanese men: The Osaka Health Survey. Diabet Med 1999; 16(11): 951-955 https://doi.org/10.1046/j.1464-5491.1999.00173.x
  14. Perry IJ, Wannamethee SG, Walker MK, Thomson AG, Whincup PH, Shaper AG. Prospective study of risk factors for development of non-insulin dependent diabetes in middle aged British men. BMJ 1995; 310(6979): 560-564 https://doi.org/10.1136/bmj.310.6979.560
  15. Medalie JH, Papier CM, Goldbourt U, Herman JB. Major factors in the development of diabetes mellitus in 10,000 men. Arch Intern Med 1975; 135(6): 811-817 https://doi.org/10.1001/archinte.135.6.811
  16. Hur NW, Kim HC, Nam CM, Jee SH, Lee HC, Suh I. Smoking cessation and risk of type 2 diabetes mellitus: Korea Medical Insurance Corporation Study. Eur J Cardiovasc Prev Rehabil 2007; 14(2): 244-249 https://doi.org/10.1097/01.hjr.0000239474.41379.79
  17. Jee SH, Suh I, Kim IS, Appel LJ. Smoking and atherosclerotic cardiovascular disease in men with low levels of serum cholesterol: The Korea Medical Insurance Corporation Study. JAMA 1999; 282(22): 2149-2155 https://doi.org/10.1001/jama.282.22.2149
  18. Kim SG, Lim HS, Cheong HK, Kim CS, Seo HJ. Incidence and risk factors of insulin resistance syndrome in 20-59 year-old Korean male workers. J Korean Med Sci 2007; 22(6): 968-972 https://doi.org/10.3346/jkms.2007.22.6.968
  19. Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 1997; 20(7): 1183-1197 https://doi.org/10.2337/diacare.20.7.1183
  20. Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: Diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 1998; 15(7): 539-553 https://doi.org/10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
  21. Jarrett RJ, McCartney P, Keen H. The Bedford survey: Ten year mortality rates in newly diagnosed diabetics, borderline diabetics and normoglycaemic controls and risk indices for coronary heart disease in borderline diabetics. Diabetologia 1982; 22(2): 79-84
  22. Fujioka S, Matsuzawa Y, Tokunaga K, Tarui S. Contribution of intra-abdominal fat accumulation to the impairment of glucose and lipid metabolism in human obesity. Metabolism 1987; 36(1): 54-59 https://doi.org/10.1016/0026-0495(87)90063-1
  23. Nakanishi N, Suzuki K, Tatara K. Alcohol consumption and risk for development of impaired fasting glucose or type 2 diabetes in middle-aged Japanese men. Diabetes Care 2003; 26(1): 48-54 https://doi.org/10.2337/diacare.26.1.48
  24. Mokdad AH, Bowman BA, Ford ES, Vinicor F, Marks JS, Koplan JP. The continuing epidemics of obesity and diabetes in the United States. JAMA 2001; 286(10): 1195-1200 https://doi.org/10.1001/jama.286.10.1195
  25. Knowler WC, Barrett-Connor E, Fowler SE, Hamman RF, Lachin JM, Walker EA, et al. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 2002; 346(6): 393-403 https://doi.org/10.1056/NEJMoa012512
  26. Tuomilehto J, Lindstrom J, Eriksson JG, Valle TT, Hamalainen H, Ilanne-Parikka P, et al. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 2001; 344(18): 1343-1350 https://doi.org/10.1056/NEJM200105033441801
  27. Foy CG, Bell RA, Farmer DF, Goff DC Jr, Wagenknecht LE. Smoking and incidence of diabetes among U.S. adults: Findings from the insulin resistance atherosclerosis study. Diabetes Care 2005; 28(10): 2501-2507 https://doi.org/10.2337/diacare.28.10.2501
  28. Shimokata H, Muller DC, Andres R. Studies in the distribution of body fat. III. Effects of cigarette smoking. JAMA1989; 261(8): 1169-1173 https://doi.org/10.1001/jama.261.8.1169
  29. Attvall S, Fowelin J, Lager I, Von Schenck H, Smith U. Smoking induces insulin resistance: A potential link with the insulin resistance syndrome. J Intern Med 1993; 233(4): 327-332 https://doi.org/10.1111/j.1365-2796.1993.tb00680.x
  30. Eliasson B, Attvall S, Taskinen MR, Smith U. The insulin resistance syndrome in smokers is related to smoking habits. Arterioscler Thromb 1994; 14(12): 1946-1950 https://doi.org/10.1161/01.ATV.14.12.1946
  31. Eliasson M, Asplund K, Evrin PE, Lundblad D. Relationship of cigarette smoking and snuff dipping to plasma fibrinogen, fibrinolytic variables and serum insulin: The Northern Sweden MONICA Study. Atherosclerosis 1995; 113(1): 41-53 https://doi.org/10.1016/0021-9150(94)05425-I
  32. Nilsson PM, Lind L, Pollare T, Berne C, Lithell HO. Increased level of hemoglobin A1c, but not impaired insulin sensitivity, found in hypertensive and normotensive smokers. Metabolism 1995; 44(5): 557-561 https://doi.org/10.1016/0026-0495(95)90110-8
  33. Frati AC, Iniestra F, Ariza CR. Acute effect of cigarette smoking on glucose tolerance and other cardiovascular risk factors. Diabetes Care 1996; 19(2): 112-118 https://doi.org/10.2337/diacare.19.2.112
  34. Cryer PE, Haymond MW, Santiago JV, Shah SD. Norepinephrine and epinephrine release and adrenergic mediation of smokingassociated hemodynamic and metabolic events. N Engl J Med 1976; 295(11): 573-577 https://doi.org/10.1056/NEJM197609092951101
  35. Sandberg H, Roman L, Zavodnick J, Kupers N. The effect of smoking on serum somatotropin, immunoreactive insulin and blood glucose levels of young adult males. J Pharmacol Exp Ther 1973; 184(3): 787-791
  36. Hibi M, Lin A, Smeal T, Minden A, Karin M. Identification of an oncoprotein- and UVresponsive protein kinase that binds and potentiates the c-Jun activation domain. Genes Dev 1993; 7(11): 2135-2148 https://doi.org/10.1101/gad.7.11.2135
  37. Kaneto H, Xu G, Fujii N, Kim S, Bonner-Weir S, Weir GC. Involvement of c-Jun N-terminal kinase in oxidative stress-mediated suppression of insulin gene expression. J Biol Chem 2002; 277(33): 30010-30018 https://doi.org/10.1074/jbc.M202066200
  38. Kim SM, Lee JS, Lee J, Na JK, Han JH, Yoon DK, et al. Prevalence of diabetes and impaired fasting glucose in Korea: Korean National Health and Nutrition Survey 2001. Diabetes Care 2006; 29(2): 226-231 https://doi.org/10.2337/diacare.29.02.06.dc05-0481
  39. Anderson JW, Gustafson NJ, Bryant CA, Tietyen-Clark J. Dietary fiber and diabetes: A comprehensive review and practical appli-cation. J Am Diet Assoc 1987; 87(9): 1189-1197
  40. Salmeron J, Manson JE, Stampfer MJ, Colditz GA, Wing AL, Willett WC. Dietary fiber, glycemic load, and risk of non-insulindependent diabetes mellitus in women. JAMA 1997; 277(6): 472-477 https://doi.org/10.1001/jama.277.6.472