Journal of Haehwa Medicine (혜화의학회지)

Research Institute of Korean Medicine (대전대학교 한의학연구소)
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Effect of Kami-Cheongsimyeonjatang on cytokine expression with GATA3 regulation in atopic dermatitis-like skin lesions and IgE hyperproduction induced in NC/Nga mice

IgE 과대생산과 피부염이 유발된 NC/Nga생쥐의 비장세포에서 GATA3 조절에 의한 유전자 발현에 미치는 영향

  • Park, Seul-Ki (Dept. of Pediatrics, College of Oriental Medicine, Daejeon University) ;
  • Han, Jae-Kyung (Dept. of Pediatrics, College of Oriental Medicine, Daejeon University) ;
  • Kim, Yun-Hee (Dept. of Pediatrics, College of Oriental Medicine, Daejeon University)
  • 박슬기 (대전대학교 한의과대학 소아과학교실) ;
  • 한재경 (대전대학교 한의과대학 소아과학교실) ;
  • 김윤희 (대전대학교 한의과대학 소아과학교실)
  • Published : 2008.12.31
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Abstract

KCSYJT medicines controlled $CD4^+/IFN-\gamma$, and $CD4^+/CD25^+/foxp3^+$ revelation that an experiment that motive allergy immune reponse because an in vitro experiment stimulates T cells of a NC/Nga mouse same time by anti-CD40/rmIL-4, and interleukin-$1{\beta}$, IL-6, TNF-$\alpha$, and TGF-$\beta$ mRNA outturn that bear in T and B cells decreased remarkably by KCSYJT medicines. Intracellular staining of splenocytes anti-CD40/rmIL-4 plus rmIL-4 stimulated as described in a, assessed after 24 h, KCSYJT exerts a mainly immunosuppressive effect that acts at least partially through suppression of the transcription factor GATA3 expression in $CD4^+$ T cells. We found that skin lesions, which were clinically and histologically very similar to human AD, mite antigen-induced dermatitis on the face, neck, ears and dorsal skin of inbred NC/Nga mice. Result that Th1 cell and Th2 cell observe to be shifted by cytokine expression with GATA3 regulation by KCSYJT medicines could know that KCSYJT medicines can use usefully in allergy autoimmnune diease.

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