혜화의학회지 (Journal of Haehwa Medicine)
- 제17권2호
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- Pages.117-135
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- 2008
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- 2586-3002(pISSN)
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- 2586-3347(eISSN)
아토피 피부염에 대한 황토가미방(黃土加味方)과 자초복합방(紫草複合方) 겸용 연구
A Study on Combination of Topical Jachobokhabbang(JBB) and Internal Hwangtogamibang(HTGMB) for the Treatment of Atopic Dermatitis
- 하여태 (대전대학교 한의과대학 병리학교실) ;
- 최학주 (대전대학교 한의과대학 병리학교실) ;
- 김선빈 (대전대학교 한의과대학 병리학교실) ;
- 김동희 (대전대학교 한의과대학 병리학교실)
- Ha, Yo-Tae (Department of Oriental Pathology, College of Oriental Medicine, Daejeon University) ;
- Choi, Hak-Joo (Department of Oriental Pathology, College of Oriental Medicine, Daejeon University) ;
- Gim, Seon-Bin (Department of Oriental Pathology, College of Oriental Medicine, Daejeon University) ;
- Kim, Dong-Hee (Department of Oriental Pathology, College of Oriental Medicine, Daejeon University)
- 발행 : 2008.12.31
초록
In order to investigate the efficacy of a combination of JBB as topical and HTGMB as internal treatment method, changes in various immune related factors and histological changes in NC/Nga induced animal model was studied. Combined treatment of topical JBB and internal HTGMB significantly reduced the atopic dermatitis clinical index, the number of immune cells such as CD19+, CCR3+, B220+/IgE+, and Gr-1+/CD11b+ in DLN and dorsal skin, compared to the control group. Otherwise increased CD3+, CD4+/CD25+, CD8+ and CD4+ cells in the DLN. And also combined treatment of topical JBB and internal HTGMB suppressed the lymphocytes and mast cells from infiltrating into the skin tissues when stained with H&E and toluidine blue. Based on the results above, it is strongly suggested that the combined treatment of topical JBB and internal HTGMB significantly induced anti-allergic activities through immune modulation. The findings can be applied to developing a more sustainable treatment for atopic dermatitis and be helpful in practicing combined treatments in clinical treatments in the future.