Journal of Periodontal and Implant Science

Korean Academy of Periodontology (대한치주과학회)
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Study of chitosan's effects on periodontal tissue regeneration: a meta-analysis of the histomorphometry

키토산의 치주조직 재생력에 대한 연구의 고찰: 조직계측학적 메타분석

  • Yang, Jin-Hyuk (Department of Periodontology, Oral Science Research Center, College of Dentistry, Yonsei University) ;
  • Chae, Gyung-Joon (Department of Periodontology, Oral Science Research Center, College of Dentistry, Yonsei University) ;
  • Yun, Jeong-Ho (Department of Dentistry, College of Medicine, Kwandong University, Myongji Hospital) ;
  • Jung, Ui-Won (Department of Periodontology, Oral Science Research Center, College of Dentistry, Yonsei University) ;
  • Lee, Yong-Keun (Department and Research Institute of Dental Biomaterials and Bioengineering, Yonsei University College of Dentistry) ;
  • Cho, Kyoo-Sung (Department of Periodontology, Oral Science Research Center, College of Dentistry, Yonsei University) ;
  • Chai, Jung-Kiu (Department of Periodontology, Oral Science Research Center, College of Dentistry, Yonsei University) ;
  • Kim, Chong-Kwan (Department of Periodontology, Oral Science Research Center, College of Dentistry, Yonsei University) ;
  • Choi, Seong-Ho (Department of Periodontology, Oral Science Research Center, College of Dentistry, Yonsei University)
  • 양진혁 (연세대학교 치과대학 치주과학교실, 치주조직재생연구소) ;
  • 채경준 (연세대학교 치과대학 치주과학교실, 치주조직재생연구소) ;
  • 윤정호 (관동대학교 의과대학 명지병원 치과) ;
  • 정의원 (연세대학교 치과대학 치주과학교실, 치주조직재생연구소) ;
  • 이용근 (연세대학교 치과대학 치과생체재료공학교실 및 연구소) ;
  • 조규성 (연세대학교 치과대학 치주과학교실, 치주조직재생연구소) ;
  • 채중규 (연세대학교 치과대학 치주과학교실, 치주조직재생연구소) ;
  • 김종관 (연세대학교 치과대학 치주과학교실, 치주조직재생연구소) ;
  • 최성호 (연세대학교 치과대학 치주과학교실, 치주조직재생연구소)
  • Published : 2008.03.31
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Abstract

Purpose: Chitosan & chitosan derivative(eg. membrane) have been studied in periodontal regeneration, and recently many studies of chitosan have reported good results. If chitosan's effects on periodontal regeneration are enhanced, we can use chitosan in many clinical and experimental fields. For this purpose, this study reviewed available literatures, evaluated comparable experimental models. Materials and Methods: Ten in vivo studies reporting chitosan's effects on periodontal tissue regeneration have been selected by use of the 'Pubmed' and hand searching. Results: 1. In Sprague Dawley rat calvarial defect models, amount of newly formed bone in defects showed significant differences between chitosan/chitosan-carrier/chitosan-membrane groups and control groups. 2. In beagle canine 1-wall intrabony defect models, amount of new cementum and new bone showed significant differences between chitosan/chitosan-membrane groups and control groups. The mean values of the above experimental groups were greater than the control groups. Conclusion: The results of this study have demonstrated that periodontal regeneration procedure using chitosan have beneficial effects, which will be substitute for various periodontal regenerative treatment area. One step forward in manufacturing process of chitosan membrane and in use in combination with other effective materials(eg. bone graft material or carrier) may bring us many chances of common use of chitosan in various periodontal area.

Keywords

References

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