한국대기환경학회지 (Journal of Korean Society for Atmospheric Environment)

  • 제24권3호
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  • Pages.321-328
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  • 2008
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  • 1598-7132(pISSN)
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  • 2383-5346(eISSN)
한국대기환경학회 (Korean Society for Atmospheric Environment)
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생쥐에서 가정분진 입자로 인한 항원관련 호산구성 기도 염증과 기도 과민성의 증대

Enhancement of Allergen-related Eosinophilic Airway Inflammation and Airway Hyperresponsiveness by House Dust Particles in Mice

  • 임흥빈 (충북대학교 농업생명환경대학 특용식물학과) ;
  • 김승형 (대전대학교 한의과대학 동서생명과학연구원)
  • Lim, Heung-Bin (Department of Industrial Crop Science & Technology, Chungbuk National University) ;
  • Kim, Seung-Hyung (Institute of Traditional Medicine & Bioscience, Daejeon University)
  • 발행 : 2008.06.30
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초록

The number of patient with allergic asthma and atopy have increased in the cities of Korea steadily. In order to elucidate the primary factor, we investigated whether the house dust particles collected from an apartment of the middle classes has promoting effects of allergen-related airway inflammation and airway hyperresponsiveness. Mice were treated with 0.1 mL of 1 mg/mL of house dust particles suspension by intratracheal instillation once weekly for 10 weeks combined with ovalalbumin (OVA) sensitization. Intratracheal instillation of house dust particles and OVA sensitization caused an increase in the level of serum L-lactate dehydrogenase (LDH), immunoglobulun-E (IgE) and histamine, and an elevation in respiratory resistance. It also enhanced infiltration of eosinophils in the bronchoalveolar lavage fluid (BALF) of mice, IgE and eotaxin expression in blood, and T helper type 2 cell derived cytokine levels such as of interleukin (IL)-4, IL-13 and IL-5 in the BALF. However, it did not influence T helper type 1 cytokine such as interferon-gamma in the BALF. These results indicate that house dust particles elevate allergen-related airway inflammation and airway hyperresponsiveness in mice and may play an important role in the aggravation of asthma and atopy in Korea.

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참고문헌

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