Journal of Oriental Neuropsychiatry (동의신경정신과학회지)

The Korean Society of Oriental Neuropsychiatry (대한한방신경정신과학회)
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An Experimental Study on the Effect of Sinchim on Enhancing of memory in Rat with water maze

신침(神枕)이 치매유발백서의 학습을 통한 기억에 미치는 영향

  • Kim, Dong-Hyeon (Dept. of Neuropsychiatry, College of Oriental Medicine, Dongguk University) ;
  • Jeung, Hee-Sang (Dept. of Neuropsychiatry, College of Oriental Medicine, Dongguk University) ;
  • Kim, Geun-Woo (Dept. of Neuropsychiatry, College of Oriental Medicine, Dongguk University) ;
  • Koo, Byung-Soo (Dept. of Neuropsychiatry, College of Oriental Medicine, Dongguk University)
  • 김동현 (동국대학교 한의학대학 신경정신과교실) ;
  • 정희상 (동국대학교 한의학대학 신경정신과교실) ;
  • 김근우 (동국대학교 한의학대학 신경정신과교실) ;
  • 구병수 (동국대학교 한의학대학 신경정신과교실)
  • Published : 2008.03.30
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Abstract

Objectives : This study was performed to examine the effect of Sinchim on enhancing of memory in rat with water maze. Methods : Experimental animals(white rat) were classfied into normal, control, and aroma sample group. Then, they were injected .{\beta}-amyloid into control and aroma sample group rat's brain about $5{\mu}l$ to injure its brain. After rat smelt Sinchim about 12days, I did water maze test and anatomized its hippocampus. Sections were cut coronally at 30 ${\mu}m$.(XI00) Results: 1. In acquisition test of water maze learning, .{\beta}-amyloid injured group took more time than normal group to reach the escape platform noticeably and through the session of trial, Sinchim aroma sample group shortened time than .l3-amyloid injured group after 6 days. 2. In the acetyltransferase(AchE) immunostained method, it was shown that Sinchim aroma sample recovered tbe syntbesis of ChAT(Choloneacetyltransferase). Conclusion: Smelling Sinchim would be useful for enhancing of memory.

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