Journal of Life Science (생명과학회지)

Korean Society of Life Science (한국생명과학회)
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Genetic Factor of Bitter Taste Perception in Humans.

쓴맛 물질에 대한 개인 간 인지능력 차이에 대한 유전학적 연구

  • Lee, Hye-Jin (Department of Biology, College of Natural Sciences, Kyungpook National University) ;
  • Kim, Un-Kyung (Department of Biology, College of Natural Sciences, Kyungpook National University)
  • 이혜진 (경북대학교 자연과학대학 생물학과) ;
  • 김언경 (경북대학교 자연과학대학 생물학과)
  • Published : 2008.07.30
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Abstract

The ability or inability to taste phenylthiocarbamide (PTC) is a classic inherited trait that has been best-studied in human populations. Also, variation in PTC perception has been correlated with dietary preferences and thus may have important consequence for diet-related diseases in modem populations. The recent identification of the TAS2R38 gene (PTC gene) which is a member of TAS2R family of bitter taste receptor genes and three common polymorphisms in the gene is highly correlated with taste sensitivity to PTC. Balancing natural selection has acted to maintain high frequency of both alleles of the gene in human population. Future detailed studies of the relationships between molecular mechanisms and taste function may have therapeutic implications, such as helping patients to consume beneficial bitter-tasting compounds.

TAS2R38 유전자의 일배체형과 미맹 간익 관계에 대한 이해는 개인에 따라 다양한 음식 선호도의 유전학적 기초와 쓴맛에 대한 민감도로 예측할 수 있는 건강과의 관계에 관한 연구에 많은 도움을 줄 것이다. 또한, TAS2R38과 같이 생체내에서 표현형에 강력한 영향을 준다고 알려진 유전자에 대한 정보는 인간의 미각에 대한 생리학, 생화학적 기능, 분자적 구조를 설명하기 위한 연구에 중요한 정보를 제공할 것이다. 이러한 연구 결과들은 앞으로 각종 인공 감미료 등의 섭취가 증가하면서 급증하고 있는 미각장애에 대한 분자유전학적인 진단과 유전자 치료의 기틀을 마련하는데 기여할 것이다.

Keywords

References

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