대한한의학회지 (The Journal of Korean Medicine)
- 제29권3호
- /
- Pages.50-62
- /
- 2008
- /
- 1010-0695(pISSN)
- /
- 2288-3339(eISSN)
궤양성 대장염 동물모델에서 사미연견탕(四味軟堅湯)의 항염증 및 장내세균 효소활성 억제효과
Effects of Samiunkyungtang on inflammation and fecal enzymes in ulcerative colitis animal model
- Kim, So-Yeon (3rd Dept. of Internal Medicine, College of Oriental Medicine, Kyung-Hee University) ;
- Ryu, Bong-Ha (3rd Dept. of Internal Medicine, College of Oriental Medicine, Kyung-Hee University) ;
- Park, Jae-Woo (3rd Dept. of Internal Medicine, College of Oriental Medicine, Kyung-Hee University)
- 발행 : 2008.07.31
초록
Objectives: This study was aimed to find the effect of Samiunkyungtang on inflammation and microflora in an ulcerative colitis animal model. Methods: We established four groups of normal, control, test 1, and test 2 and assigned 6 rats toeach group. The normal group was not treated by any process and fed by normal saline. The control & test groups were provided with 4% dextran sodium sulfate (DSS) treatment for 7 days. Samiunkyungtang extract was orally administered to test groups (test 1=25mg/kg, test 2 100mg/kg) 3 days after DSS treatment for 10 days. After DSS treatment finished, we sacrificed the mice and measured colon length and enzyme activities such as myeloperoxidase (MPO), alkine phosphatase (ALP),