동의신경정신과학회지 (Journal of Oriental Neuropsychiatry)

  • 제19권2호
  • /
  • Pages.151-163
  • /
  • 2008
  • /
  • 1226-6396(pISSN)
  • /
  • 2234-4942(eISSN)
대한한방신경정신과학회 (The Korean Society of Oriental Neuropsychiatry)
권호 표지

장원환가감방(壯元丸加減方)인 LMK02가 아밀로이드 전구단백질(前驅蛋白質)으로 형질전환(形質轉換)된 초파리에 미치는 효과

Effects of Antidementia on LMK02 in APP-transgenic Fly

  • 김상태 (이화여자대학교 생명 약학부 뇌신경연구실) ;
  • 강형원 (원광대학교 산본한방병원 신경정신과 & 인암뇌신경센타) ;
  • 한평림 (이화여자대학교 자연대학 나노과학부 뇌신경 분자연구) ;
  • 조형권 (한풍제약(주)) ;
  • 김태헌 (원광대학교 한의과대학 한방신경정신과교실) ;
  • 류영수 (원광대학교 한의과대학 한방신경정신과교실) ;
  • 손형진 (이화여자대학교 생명 약학부 뇌신경연구실)
  • Kim, Sang-Tae (Division of BioScience-Pharmacy, Ewha Womans of University) ;
  • Kang, Hyung-Won (Dept. of Neuropsychiatry and Inam Neuroscience Research Center, Wonkwang University, Sanbon Oriental Medical Center) ;
  • Han, Pyeong-Leem (Division of Nanoscience, Ewha Womans of University) ;
  • Cho, Hyoung-Kwon (ANPOONG PHARM & FOODS Co. Ltd.) ;
  • Kim, Tae-Heon (Dept. of Neuropsychiaty, Colege of Oriental Medicine, Wonkwang University) ;
  • Lyu, Yeoung-Su (Dept. of Neuropsychiaty, Colege of Oriental Medicine, Wonkwang University) ;
  • Son, Hyeong-Jin (Division of BioScience-Pharmacy, Ewha Womans of University)
  • 발행 : 2008.07.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Objective : Recent studies indicate that the deposition of beta-amyloid ($A{\beta}$) is related in the pathogenesis of Alzheimer's disease (AD), but the underlying mechanism is still not clear. Method : To investigate the potential cellular functions of APP and LMK02, we use transgenic drosophila as a model was treated with either LMK02, and the effect in APP expression was determined by climbing assay. LMK02 have been shown to be neuroprotective in fly model systems. We asked whether dietary supplementation with LMK02 would influence behavior and AD-like pathology in a transgenic fly model. Result LMK02 water extract have attenuated fly death in vivo. LMK02-treated fly increased percentage of flight ability more longly and survival ratio more than controls. APP-GRIM drosophila treated with LMK02 had significantly less accumulation of APP deposition in the eye and brain as compared to control drosophila. Conclusion : These results suggest that LMK02 prevent APP-induced neurotoxicity through attenuating flies death induced by APP, and may be useful as potential therapeutic agents for AD.

키워드