Journal of Oriental Neuropsychiatry (동의신경정신과학회지)

The Korean Society of Oriental Neuropsychiatry (대한한방신경정신과학회)
권호 표지

The Effects of KakamBoyangHwanoh-Tang(KBHT) and PalMihapChongMung-Tang(PMCMT) on Protecting Microglia and Inhibiting Acetylcholinesterase and Oxidants

가미보양환오탕(加味補陽還五湯)과 팔미합총명탕(八味合聰明湯)의 microglia 보호, 항산화 및 acetylcholinesterase 억제 효과

  • Kim, Hyun-Joo (Department of Oriental Neuropsychiatry, Oriental Medicine, Daejeon University) ;
  • Lee, Sang-Ryong (Department of Oriental Neuropsychiatry, Oriental Medicine, Daejeon University)
  • 김현주 (대전대학교 한의과대학 신경정신과학교실) ;
  • 이상룡 (대전대학교 한의과대학 신경정신과학교실)
  • Published : 2008.07.30
Download PDF
⟨ Previous Next ⟩

Abstract

Objective : This experiment was designed to investigate the effect of the KBHT and PMCMT extract on protecting microglia and inhibiting acetylcholinesterase and oxidants. Method : The effects of the KBHT and PMCMT extract on cell death of BV2 microglial cell line treated by ${\gamma}$ ; expression of NO, ROS in BV2 microglial cell line treated by lipopolysaccharide(LPS) ; AChE activity in PC-12 cell treated by NGF were investigated, respectively. Result : The KBHT and PMCMT extract significantly increased cell viability in BV2 microglial cell line treated with ${\gamma}$. The KBHT and PMCMT extract suppressed the NO and ROS production in BV2 microglial cell line treated by LPS. The KBHT and PMCMT extract groups also showed inhibition of AChE activity in PC-12 cell line. Conclusion : According to the above result, it is suggested that the KBHT and PMCMT extract might be usefully applied for prevention and treatment of Alzheimer' s disease.

Keywords