대한한방소아과학회지 (The Journal of Pediatrics of Korean Medicine)

  • 제22권1호
  • /
  • Pages.103-111
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  • 2008
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  • 1226-8038(pISSN)
  • /
  • 2287-9463(eISSN)
대한한방소아과학회 (The Association of Korean Oriental Pediatrics)
권호 표지

승갈탕(升葛湯)의 제형변화에 따른 항알레르기 효과의 비교 연구

The Comparative Study on the Difference of Anti-allergic Effects Based on Different Form of Seunggal-tang

  • 이승연 (동의대학교 한의학임상연구센터) ;
  • 강경화 (동의대학교 한의과대학 생리학교실) ;
  • 이해웅 (동의대학교 한의과대학 예방의학교실) ;
  • 유선애 (동의대학교 한의과대학 소아과학교실) ;
  • 김홍배 (동의대학교 한의과대학 소아과학교실) ;
  • 류지효 (동의대학교 한의학임상연구센터)
  • Lee, Seung-Yeon (Clinical Research Center of Oriental Medicine, Dongeui University) ;
  • Kang, Kyung-Hwa (Department of Physiology, College of Oriental Medicine, Dongeui University) ;
  • Lee, Hai-Woong (Department of Public Health, College of Oriental Medicine, Dongeui University) ;
  • Lyu, Sun-Ae (Department of Pediatrics, College of Oriental Medicine, Dongeui University) ;
  • Kim, Hong-Bae (Department of Pediatrics, College of Oriental Medicine, Dongeui University) ;
  • Lyu, Ji-Hyo (Clinical Research Center of Oriental Medicine, Dongeui University)
  • 발행 : 2008.04.30
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초록

Objectives Seunggal-tang is one of the prescriptions of oriental herbal medicine, which has been applied to several allergic diseases such as atopic dermatitis. This study was planned to compare differences of anti-allergic effects based on different form of Seunggal-tang by manufacturing differently. Methods Two types herb medicine products were used; aqueous extract (SG-T, Seunggal-Tang) and powder (SG-S, Seunggal-San) which were made from the same mixed formula of Seunggal-tang. To investigate in vitro anti-allergic activities, rat basophilic leukemia (RBL-2H3) cells were treated with SG-T and SG-S for 1 hour, and then stimulated with the phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187. We examined the release of beta-hexosaminidase, as a marker of degranulation, and the releases of tumor necrosis factor (TNF)-alpha and interleukin (IL)-4, as proinflammatory cytokines. Results SG-T and SG-S didn't have effects on cell viabilities in concentrations under 2㎎/㎖. In additionto that, SG-T more inhibited releasing ${\beta}$-hexosaminidase, TNF-${\alpha}$ and IL-4 than SG-S. Conclusions These results indicate that SG-T is more effective against mast cell-mediated allergic reactions than SG-S.

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