Anxiety and mood (대한불안의학회지)

Korean Academy of Anxiety Disorders (대한불안의학회)
권호 표지

Preliminary Study for Changes in Brain Perfusion in the Drug-Naive Patients with Panic Disorder with SPECT Following Cognitive-Behavioral Therapy

약물에 노출되지 않은 공황장애 환자들에서 인지행동치료 후 뇌혈류 변화에 대한 예비연구

  • Kim, Jung-Bum (Department of Psychiatry, Keimyung University School of Medicine) ;
  • Shin, Young-Ah (Department of Psychiatry, Keimyung University School of Medicine) ;
  • Chae, Jeong-Ho (Department of Psychiatry, College of Medicine, The Catholic University of Korea) ;
  • Chang, Eun-Jin (Department of Psychiatry, Keimyung University School of Medicine) ;
  • Ryu, Seol-Young (Department of Psychiatry, Keimyung University School of Medicine) ;
  • Won, Kyoung-Sook (Department of Radiology, Keimyung University School of Medicine) ;
  • Zeon, Seok-Kil (Department of Radiology, Keimyung University School of Medicine) ;
  • Chung, Yong-An (Department of Radiology, College of Medicine, The Catholic University of Korea)
  • 김정범 (계명대학교 의과대학 정신과학교실) ;
  • 신영아 (계명대학교 의과대학 정신과학교실) ;
  • 채정호 (가톨릭대학교 정신과학교실) ;
  • 장은진 (계명대학교 의과대학 정신과학교실) ;
  • 류설영 (계명대학교 의과대학 정신과학교실) ;
  • 원경숙 (계명대학교 의과대학 핵의학교실) ;
  • 전석길 (계명대학교 의과대학 핵의학교실) ;
  • 정용안 (가톨릭대학교 핵의학교실)
  • Received : 2008.09.20
  • Accepted : 2008.10.12
  • Published : 2008.10.30
Download PDF
⟨ Previous Next ⟩

Abstract

Objective : Although cognitive-behavior therapy (CBT) is effective in patients with panic disorder, its the-rapeutic mechanism of action in the brain remains unclear. This study was performed to investigate regional blood flow changes associated with successful completion of CBT in drug-naive patients with panic disorder. Method : The regional blood flow in 4 patients with panic disorder was compared to that in 11 healthy controls before and after a 12-week group CBT using $^{99m}Tc$-ECD SPECT imaging. Psychopathology was assessed using Panic Disorder Severity Scale. Data were analyzed using software for statistical parametric mapping (SPM2). Results : Before CBT, significantly decreased blood flow was found in the parietal and occipital area in panic patients than normal volunteers. In all the patients who showed remission after CBT, increased blood flow was detected in the right cingulate gyrus, left lingual gyrus, and left superior parietal lobule, whereas decreased blood flow was seen in the left inferior temporal gyrus. Conclusion : These results suggested that CBT is effective for panic disorder and change the activity of cingulate gyrus and left temporal gyrus, a part of the brain areas associated with fear in panic disorder.

Keywords