Korean Journal of Agricultural Science (농업과학연구)
- Volume 35 Issue 2
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- Pages.177-182
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- 2008
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- 2466-2402(pISSN)
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- 2466-2410(eISSN)
Host Cell-Intrinsic Antiviral Defense Induced by Type I Interferons
- Asano, Atsushi (Laboratory of Veterinary Biochemistry, School of Veterinary Medicine, Faculty of Agriculture, Tottori University)
- Received : 2008.11.14
- Accepted : 2008.12.08
- Published : 2008.12.30
Abstract
Type I Interferons (IFNs) are potent antiviral cytokines that modulate both innate immunity and adaptive immunity. Type I IFNs are immediately induced by viral infection, and stimulate production of a broad range of gene products such as double-stranded RNA-activated protein kinase (PKR), 2' 5'-oligoadenylate synthetase (OAS)/RNaseL and Mx GTPases. These proteins inhibit viral replication in host cells. Type I IFNs, in turn, lead to antiviral state at early phase of viral infection. We provide an overview of the knowledge of IFN-inducible antiviral proteins conserved in vertebrates.