Antioxidant and Anticancer Effects of Agrimony (Agrimonia pilosa L.) and Chinese Lizardtail (Saururus chinensis Baill)

짚신나물, 삼백초의 항산화와 항암활성 효과

  • Seo, Hun-Seok (Department of Crop Science, College of Agriculture, Chungbuk National University) ;
  • Chung, Bong-Hwan (Seowon University Bio Organic Material & Food Center) ;
  • Cho, Yong-Gu (Department of Crop Science, College of Agriculture, Chungbuk National University)
  • 서훈석 (충북대학교 농업생명환경대학 식물자원학과) ;
  • 정봉환 (서원대학교 친환경 바이오소재 및 식품센터) ;
  • 조용구 (충북대학교 농업생명환경대학 식물자원학과)
  • Published : 2008.06.30

Abstract

The antioxidant activities of Agrimony (Agrimonia pilosa L.) and Chinese lizardtail (Saururus chinensis Baill) according to extraction methods were measured. SOD-like activity showed greater antioxidant effects with ethanol solvent than those with water. Ethanol extracts of Agrimony leaves showed the highest SOD-like activity of 94.4%. SOD-like activity differed according to the extraction solvents. The contents of polyphenolic compounds were higher in water extracts than those in ethanol extracts. The contents were 161.4 mg for Agrimony roots, 100.2 mg for Agrimony leaves, and 79.1 mg for Agrimony stalks in order. EDA in Agrimony leaves that were highest among medicinal plants were 83.4% in the water extract and 81.7% in the ethanol extract. The anticancer effects of the extracts by water and ethanol from Agrimony and Chinese lizardtail were experimented. The growth of stomach cancer cells, SNU-719 was inhibited 94.5% by the hexane fractions of Agrimony and also the growth of liver cancer cells, Hep3B was inhibited 83.2% by the hexane fractions of Agrimony, while the growth of normal cell, DC2.4 was not affected.

Keywords

References

  1. An DH, Cho SJ, Jung ES, Lee HJ, Hwang JH, Park EJ, Park HR, Lee SC (2006) Antioxidant and anticancer activities of water extracts from Ceramium kondoi. J. Korean Soc. Food Sci. Nutr. 35(10):1304-1308 https://doi.org/10.3746/jkfn.2006.35.10.1304
  2. Blois MS (1958) Antioxidant determination by the use of a stable free radical. Nature 26:1198-1202
  3. Cao LH, Lee JK, Cho KH, Kang DG, Kwon TO, Kwon JW, Kim JS, Sohn EJ, Lee HS (2006) Mechanism for the vascular relaxation induced by butanol extract of Agrimonia pilosa. Kor. J. Pharmacogn. 37(2):67-73
  4. Cha BC, Lee EH (2007) Antioxidant activities of flavonoids from the leaves of Smilax china Linne. Kor. J. Pharmacogn. 38(1):31-36
  5. Han SH, Woo NRY, Lee SD, Kang MH (2006) Antioxidative and antibacterial activities of endemic plants extracts in plants. Korean J. Medicinal Crop Sci. 14(1):49-55
  6. Ju JC, Shin JH, Lee SJ, Cho HS, Sung NJ (2006) Antioxidative activity of hot water extracts from medicinal plants. J. Korean Soc. Food Sci. Nutr. 35(1):7-14 https://doi.org/10.3746/jkfn.2006.35.1.007
  7. Kang BS (1992) Medical herbs. Young Rym Sa. Seoul. p. 384-386
  8. Kang SC, Lee CM, Koo HJ, Ahn DH, Choi H, Lee JH, Bak JP, Lee MH, Choung ES, Kawk JH, Lee MK (2006) Hepatoprotective effects of aqueous extract from aerial part of agrimmony. Kor. J. Pharmacogn. 37(1):28-32
  9. Lee JH, Kim YG, Choi MI (2005) Effects of cytotoxic and antioxidant of methanol extracts from medicinal plants. The Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology 18(3):37-43
  10. Lee SO, Lee HJ, Yu MH, Im HG, Lee IS (2005) Total polyphenol contents and antioxidant activities of methanol extracts from vegetables produced in ullung island. Korean J. Food Sci. Technol. 37:233-240
  11. Lee ST, Lee YH, Choi YJ, Lee YH, Cho JS, Heo JS (2001) Yield and bioactive component on different compost amounts and cultural methods of Saururus chinensis $B_{AILL}$ . Korean J. Medicinal Crop Sci. 9(3):220-224
  12. Lee YH, Kim MB, Chung DS (2002) Effect of extract Agrimonia pilosa L. on biological activity in rats. Korean J. Medicinal Crop Sci. 10(3):167-170
  13. Lee YM, Shin HD, Lee JJ, Lee MY (2007) Antioxidative effect of Chaenomelis Fructus ethanol extract. Korean J. Food Preserv. 14(2):177-182
  14. Lee YN (2002) Flora of Korea. Kyo Hak Publishing Co. Ltd. Seoul. p. 218-219
  15. Marklund S, Gudrun M (1974) Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur. J. Biochem. 47:469-474 https://doi.org/10.1111/j.1432-1033.1974.tb03714.x
  16. Park Y, Boo HO, Park YL, Cho DH, Lee HH (2007) Antioxidant activity of Momordica charantia L. extracts. Korean J. Medicinal Crop Sci. 15(1):56-61
  17. Slinkard K, Singleton VL (1977) Total phenol analysis: automation and comparison with manual method. Am. J. Ecol. Vitic. 28(1):49-56
  18. Yang HJ, Park SN (2007) Evaluation of antioxidant potential of extract/fractions of Equisetum arvense (I). J. Soc. Cosmet. Scientists Korea 33(2):61-67