Applied Biological Chemistry

The Korean Society for Applied Biological Chemistry (한국응용생명화학회)
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Phytochemical Constituents of Climacium dendroides

곧은 나무이끼(Climacium dendroides)의 식물 화학적 성분연구

  • Nam, Jung-Hwan (Highland Agricultural Institute, Rural Development Administration) ;
  • Cho, In-Sook (Highland Agricultural Institute, Rural Development Administration) ;
  • Kim, Su-Jeong (Highland Agricultural Institute, Rural Development Administration) ;
  • Nam, Chun-Woo (Highland Agricultural Institute, Rural Development Administration) ;
  • Seo, Jong-Taek (Highland Agricultural Institute, Rural Development Administration) ;
  • Yoo, Dong-Lim (Highland Agricultural Institute, Rural Development Administration) ;
  • Kim, Won-Bae (Highland Agricultural Institute, Rural Development Administration) ;
  • Ryu, Seung-Yeol (Highland Agricultural Institute, Rural Development Administration) ;
  • Lee, Eung-Ho (Highland Agricultural Institute, Rural Development Administration) ;
  • Kim, Min-Young (Department of pharmaceutical Engineering, Sangji University) ;
  • Yoo, Young-Min (Department of pharmaceutical Engineering, Sangji University) ;
  • Park, Hee-Juhn (Department of pharmaceutical Engineering, Sangji University) ;
  • Jung, Hyun-Ju (College of Pharmacy, Wonkwang University)
  • 남정환 (농촌진흥청 고령지농업연구소) ;
  • 조인숙 (농촌진흥청 고령지농업연구소) ;
  • 김수정 (농촌진흥청 고령지농업연구소) ;
  • 남춘우 (농촌진흥청 고령지농업연구소) ;
  • 서종택 (농촌진흥청 고령지농업연구소) ;
  • 유동림 (농촌진흥청 고령지농업연구소) ;
  • 김원배 (농촌진흥청 고령지농업연구소) ;
  • 유승열 (농촌진흥청 고령지농업연구소) ;
  • 이응호 (농촌진흥청 고령지농업연구소) ;
  • 김민영 (상지대학교 제약공학과) ;
  • 유영민 (상지대학교 제약공학과) ;
  • 박희준 (상지대학교 제약공학과) ;
  • 정현주 (원광대학교 약학대학)
  • Published : 2008.06.30
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Abstract

The chromatographic separation of organic solvent extracts of liverwort led to the isolation of six compounds. 2-Chromenone (1), 3, 4-dihydroxy-cinnamic acid (2), 3, 3', 4', 5, 7-pentahydroxy-2-phenylchromen-4-one (3), kaemperol-3-O-${\beta}$-D-glucopyranoside (4), 3-[[3-(3,4-Dihydroxyphenyl)-1-oxo-2-propenyl]oxy]-1, 4, 5-trihydroxycyclohexane carboxylic acid (5) and quercetin-3-O-rutinoside (6) were isolated from the methanolic extracts of the all part of Climacium dendroides. Their structure were established by chemical and spectroscopic methods. All compounds were isolated for the first time from this plant Climacium dendroides.

곧은 나무이끼의 전초에서 물질을 분리 및 동정하기 위해 곧은 나무이끼의 MeOH 추출물을 $CHCl_3$, EtOAc 및 BuOH로 용매 분획하였다. $CHCl_3$ 분획으로부터 2-chromenone(coumarin)을 분리 하였고 EtOAc 분획에서 3,4-dihydroxy-cinnamic acid (caffeic acid), 3,3',4',5,7-pentahydroxy-2-phenyl-chromen-4-one (quercetin)과 kaemperol-3-O-${\beta}$-D-glucopyranoside(astragalin)을 분리하였다. BuOH 분획으로부터 3-[[3-(3,4-Dihydr oxyphenyi)-1-oxo-2-propenyl]oxy]-1,4,5-trihydroxycyclohexanecarboxylic acid(chlorogenic acid)와 quercetin-3-O-rutinoside(rutin)를 분리하여 IR, UV, Mass, NMR과 이화학적인 방법으로 그 구조를 규명하였다. 곧은 나무이끼에서 이 물질들이 분리된 것은 처음으로 보고되는 것이다.

Keywords

References

  1. Jung, H. W., Choi, J. Y., Lee, J. G., Choi, E, H., Oh, J. S., Kim, D. C., Kim. J. A., Park , S. H., Son, J. K. and Lee, S. H. (1978) Isolation of melanogenesis inhibitors from Cinnamomi Cortex. Kor. J. Phamacogn. 38, 382-386
  2. Min, B. S. (2006) Coumarins and polyacetylene from the roots of Angelica purpuraefolia. Nat. Prod. Sci. 12, 129-133
  3. Lee, S. H., Kang, S. S. and Shin, K. H. (2002) Coumarins and pyrimidine from Angelica gigas roots. Nat. Prod. Sci. 8, 58-61
  4. Moon, H. I. and Zee, O. P. (1999) Anticancer compounds of Plantago asiatica L. Kor. J. Medicinal Crop Sci. 7, 143-146
  5. Mukherjee, K. K., Mitra, S. K. and Ganguly, S. N. (1998) A new Coumarin from the seeds of Jute Corchorus olitorius L. Nat. Prod. Sci. 4, 51-52
  6. Jang, C. H., Eun, J. S., Lim, J. P., Park, H. W., Kim, J. W., Shin, T. Y., Eom, D. O., Baek, N. I. and Kim, D. K. (2003) Phytochemical components from the whole plants of Bothriospermum tenellum. Kor. J. Phamacogn. 34, 119-122
  7. Kwon, Y. S., In, K. K. and Kim, C. M. (2000) Chemical constituents from the roots of Ostericum koreanum. Kor. J. Phamacogn. 31, 284-287
  8. Lee, M. W. (2002) Phenolic compound from Lepisorus thunbergianus. Kor. J. Phamacogn. 31, 284-287
  9. Park, S. S. (1973) Studies on polyphenols in higher plants (II). Kor. J. Phamacogn. 4, 67-70
  10. Kim, T. H. (1975) Studies on unutilized plant resources (I) components of wild edible plants. Kor. J. Phamacogn. 6, 23-27
  11. Park, J. C., Park, J. G., Hur, J. S., Choi, M. R., Yoo, E. J., Kim, S. H., Son, J. C. and Kim, M. S. (2004) Inhibitory effects of methanol extract, phenolic acids and favonoids from the leaves of Eucalyptus darylmpleana against 1, 1-diphenyl-2- picrylhydrazyl radical. Nat. Prod. Sci 10, 244-247
  12. Huong, D. T., Dat, N. T., Cai, X. F. and Shen, G. (2004) Phenolic components from the leaves and twinges of Rhamnus taquetii. Kor. J. Pharmacogn. 35, 139-142
  13. Lee, E. H., Kim, H. J., Song, Y. S., Jin, C. B., Lee, K. T., Cho, J. S. and Lee, Y. S. (2003) Constituents of the stems and fruits of Opuntia ficusindica var.saboten. Arch. Pharm. Res. 26, 1018-1023 https://doi.org/10.1007/BF02994752
  14. Lee, M. S., Lim, S. C. and Park, H. J. (1994) Phthalate ester and flavonoids isolated from leaves of Erythronium japonicum. Kor. J. Medicinal Crop Sci. 2, 67-72
  15. Won, H. M., Kwon, Y.S., Lee, J. H. and Kim C. M. (2004) Chemical constituents of the leaves of Weigela subsesillis. Kor. J. Phamacogn. 35, 1-5
  16. Kim, D.K., Kwak, J. H., Song, K. W., Kwon, H. C., Zee, O. P. and Lee, K. R. (1996) Phytochemical constituents from Aconitum pseudolaeverectum Var. Kor. J. Phamacogn. 27, 75-79
  17. Kim, M. J., Kwon, Y. S. and Yu, C. Y. (2005) Antioxidative compounds in extracts of Eleutherococcus senticosus Max. Kor. J. Medicinal Crop Sci. 13, 194-198
  18. Lee, M. W. (1998) Phenolic compound from Lepisorus thunbergianus. Kor. J. Phamacogn. 29, 142-144
  19. Chung, D. K., Kim, T. H. and Lee YR (1978) The chemical screening of Caryophyllaceae Plants. Kor. J. Phamacogn. 9, 83-88
  20. Park, S. S. and Jung, S. H.(1975) Studies on polyphenols in higher plants (IV). Kor. J. Phamacogn. 6, 93-99
  21. Agrawal, P. K. (1989) Carbon-13 NMR of flavonoids, 335-337 Elsevier
  22. Nam, J. H., Choi, S. Z. and Lee, K. R. (2004). Phytochemical constituents of Synurus excelsus. Kor. J. Phamacogn. 35, 116-121