Molecular & Cellular Toxicology

  • 제4권2호
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  • Pages.150-156
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  • 2008
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  • 1738-642X(pISSN)
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  • 2092-8467(eISSN)
대한독성유전 단백체학회 (The Korean Society of Toxicogenomics and Toxicoproteomics)
권호 표지

Photoprotective Effects of Minerals from Korean Indigenous Ores on UVA-irradiated Human Dermal Fibroblast

  • Kang, Dong-Kyu (Department of Medical Biotechnology, SoonChunHyang University) ;
  • Lee, Mi-Young (Department of Medical Biotechnology, SoonChunHyang University)
  • 발행 : 2008.06.30
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초록

The photoprotective effects of minerals from Korean indigenous ores, consisting mainly of sericite, on UVA-irradiated human dermal fibroblast (HDF) were examined. Zymographic analysis showed that the treatment of the minerals significantly reduced the UVA-enhanced MMP-1 activity and mRNA level. The minerals also showed strong inhibitory effect on MMP-2 activity and mRNA expression. Moreover, the minerals were better than polyphenol in reducing MMP-1 and MMP-2 expressions. Notably, the minerals significantly enhanced collagen biosynthesis in the HDF. Inhibition of the elastase activity and protection against the oxidatively damaged HDF cell were also found in the presence of the minerals. Taken together, the ore minerals may be used as the potent photo-protective and anti-skin-aging ingredients which can prevent skin cell damage by UVA.

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참고문헌

  1. Bunnell, J. E. Medical geology: an emerging discipline on the ecosystem human health interface. Ecohealth 1:15-18 (2004) https://doi.org/10.1007/s10393-004-0068-8
  2. Isabel Carretero, M. Clay minerals and their beneficial effects upon human health. Appl Clay Sci 21:155-163 (2002) https://doi.org/10.1016/S0169-1317(01)00085-0
  3. Selinus, O. Medical geology: an emerging speciality. Terrae 1:A1-A8 (2004)
  4. Celso de Sousa, F. G. & Joao Baptista, P. S. Minerals and clay minerals in medical geology. Applied Clay Sci 36:4-21 (2007) https://doi.org/10.1016/j.clay.2006.08.006
  5. Viseras, C., Aguzzi, C., Cerezo, P. & Lopez-Galindo, A. Uses of clay minerals in semisolid health care and therapeutic products. Applied Clay Sci 36:37-50 (2007) https://doi.org/10.1016/j.clay.2006.07.006
  6. Hong, M. H. Mineral oriental drugs in Korea(I). Kor J Pharmacol 6:5-74 (1975)
  7. Lee, J. Y. et al. A geological and oriental medical study on Talc in 'Donguebogam'. J Sci Edu 23:101-114 (1999)
  8. Robinson, P. Woodlands clay-sericite mica in a claylike state. Appl Clay Sci 2:14-20 (1984)
  9. Tokubo, K. Sericite and muscovite. Fragrance J 80:60 (1998)
  10. Lee, S. M. et al. The Anti-inflammatory effect of IH- 901 in HT-29 Cells. Mol Cell Toxicol 3:254-261 (2007)
  11. Kim, Y. J., Song, M. & Ryu, J. C. Identification of differentially expressed genes (DEGs) by malachite green in HepG2 Cells. Mol Cell Toxicol 4:22-30 (2008)
  12. Barbara, A. & Glichrest, M. D. Skin aging and photoaging: An overview. J Am Acad Dermatol 21:610-613 (1989) https://doi.org/10.1016/S0190-9622(89)70227-9
  13. Seo, J. Y., Cho, K. H., Eun, H. C. & Jung, J. H. Skin aging from phenotype to mechanism. Kor J Invest Dermatol 8:187-194 (2001)
  14. Miyachi, Y. Photoaging from an oxidative standpoint. J Dermatol Sci 9:79-86 (1995) https://doi.org/10.1016/0923-1811(94)00363-J
  15. Bornstein, P. & Sage, H. Structually distinct collagen types. Annu Rev Biochem 49:957-1003 (1980) https://doi.org/10.1146/annurev.bi.49.070180.004521
  16. Breul, S. D. et al. Control of collagen production by human diploid lung fibroblasts. J Biol Chem 255: 5250-5260 (1980)
  17. Hance, A. J. & Crystal, R. G. Rigid control of synthesis of collagen types I and III by cells in culture. Nature 268:152-154 (1977) https://doi.org/10.1038/268152a0
  18. Li, Y. L. et al. Regulatory role of extracellular matrix components in expression of matrix metalloproteinases in cultured hepatic stellate cells. Cell Str Func 24:255-261 (1999) https://doi.org/10.1247/csf.24.255
  19. Kivirikko, K. I. & Prockop, D. J. Enzymatic hydroxylation of proline and lysine in protocollagen. Proc Natl Acad Sci U S A 57:782-789 (1962)
  20. Rosenbloom, J., Harsch, M. & Jimenez, S. Hydroxyproline content determines the denaturation temperature of chick tendon collagen. Arch Biochem Biophys 158:478-484 (1973) https://doi.org/10.1016/0003-9861(73)90539-0
  21. Levene, C. I. & Bates, C. J. Ascorbic acid and collagen synthesis in cultured fibroblasts. Ann N Y Acad Sci 258:288-306 (1975) https://doi.org/10.1111/j.1749-6632.1975.tb29289.x
  22. Geesin, J. C. et al. Ascorbic acid specifically increases type I and III procollagen messenger RNA levels in human skin fibroblast. J Invest Dermatol 90:420-424 (1988) https://doi.org/10.1111/1523-1747.ep12460849
  23. Pinnell, S. R., Murad, S. & Darr, D. Induction of collagen synthesis by ascorbic acid. Arch Dermatol 123:1684-1686 (1987) https://doi.org/10.1001/archderm.123.12.1684
  24. Katiyar, S. K., Afaq, F., Perex, A. & Mukhtar, H. Green tea polyphenol (-)-epigallocatechin-3-gallate treatment of human skin inhibits ultraviolet radiation induced oxidative stress. Carcinogenesis 22:287-294 (2001) https://doi.org/10.1093/carcin/22.2.287
  25. Taddese, S., Weiss, A. S., Neubert, R. H. & Schmelzer, C. E. Mapping of macrophage elastase cleavage sites in insoluble human skin elastin. Matrix Biol (2008)
  26. Clerkin, J. S., Naughton, R., Quiney, C. & Cotter, T. G. Mechanisms of ROS modulated cell survival during carcinogenesis. Cancer Lett (2008)
  27. Goetz, M. E. & Luch, A. Reactive species: A cell damaging rout assisting to chemical carcinogens. Cancer Lett (2008)
  28. Nishikawa, M. Reactive oxygen species in tumor metastasis. Cancer Lett (2008)
  29. Greul, A. K. et al. Photoprotection of UV-irradiated human skin: an antioxidative combination of vitamins E and C, carotenoids, selenium and proanthocyanidins. Skin Pharmacol Appl Skin Physiol 15:307-315 (2002) https://doi.org/10.1159/000064534
  30. Kim, Y. H. et al. Anti-wrinkle activity of ziyuglycoside I isolated from a Sanguisorba officinalis root extract and its application as a cosmeceutical ingredient. Biosci Biotechnol Biochem 72:303-311 (2008) https://doi.org/10.1271/bbb.70268
  31. Conley, S. M., Bruhn, R. L., Morgan, P. V. & Stamer, W. D. Selenium's effects on MMP-2 and TIMP- 1 secretion by human trabecula meshwork cells. Invest Ophthalmol Vis Sci 45:473-479 (2004) https://doi.org/10.1167/iovs.03-0767
  32. Hoffmann, P. R. & Berry, M. J. The influence of selenium on immune responses. Mol Nutr Food Res (2008)
  33. Birkedal-Hansen, H. et al. Matrix metalloproteinases: A review. Crit Rev Oral Biol and Med 4:197-250 (1993) https://doi.org/10.1177/10454411930040020401
  34. Williams, S. N. et al. Comparative studies on the effects of green tea extracts and individual tea catechins on human CYP1A gene expression. Chem Biol Inter 128:211-229 (2000) https://doi.org/10.1016/S0009-2797(00)00204-0