Natural Product Sciences

  • 제14권2호
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  • Pages.118-121
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  • 2008
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  • 1226-3907(pISSN)
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  • 2288-9027(eISSN)
한국생약학회 (The Korean Society of Pharmacognosy)
권호 표지

Antifibrotic Activity of Manassantin B from Saururus chinensis in HSC-T6 Hepatic Stellate Cells

  • Lee, Mi-Kyeong (Institute for Life Science, Elcom Science Co. Ltd) ;
  • Yang, Hye-kyung (College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University) ;
  • Yang, Eun-Sun (College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University) ;
  • Kim, Young-Choong (College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University) ;
  • Sung, Sang-Hyun (College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University)
  • 발행 : 2008.06.30
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초록

Manassantin B, a dilignan isolated from Saururus chinensis, significantly inhibited proliferation in HSC-T6 cells in concentration- and time-dependent manners. In addition, treatment of HSC-T6 cells with manassantin B changed cell morphology from flattened myofibroblastic membranous morphology, representing activation state, to slender shape, representing quiescent state. Furthermore, manassantin B effectively reduced collagen content in HSC-T6 cells. These results suggested that manassantin B exerted antifibrotic activity in HSCT6 cells, in part, via inhibition of cell proliferation and decrease of collagen production.

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참고문헌

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