Journal of Life Science (생명과학회지)

Korean Society of Life Science (한국생명과학회)
권호 표지
DOI QR코드

DOI QR Code

The Role of Mast Cells in Innate and Adaptive Immunity.

선천면역 및 적응면역에서 비만세포의 기능

  • Kim, Young-Hee (Department of Molecular Biology, College of Natural Sciences, Pusan National University)
  • 김영희 (부산대학교 자연과학대학 분자생물학과)
  • Published : 2008.06.30
Download PDF
⟨ Previous Next ⟩

Abstract

The function of mast cells as effector cells in allergy has been extensively studied. Mast cells activated through high affinity IgE-receptor ($Fc{\varepsilon}RI$) release diverse mediators, and lead to smooth muscle constriction, vasodilation, increase of vascular permeability, leukocyte recruitment and activation, mucus secretion, and tissue proliferation and remodeling. However, various other immunological and non-immunological signals can lead to the activation of mast cells. In resent years, mast cells have been identified to be involved in a complex range of immune functions. Mast cells can be important as key players in the regulation of innate as well as adapted immune responses, and may influence the development of allergy, autoimmune disorder and peripheral tolerance. This review summarizes the recent advances in the understanding of effector functions of mast cells in immune responses.

Keywords

References

  1. Agosti, V., S. Corbacioglu, I. Ehlers, C. Waskow, G. Sommer, G. Berrozpe, H. Kissel, C. M. Tucker, K. Manova, M. A. Moore, H. R. Rodewald and P. Besmer. 2004. Critical role for kit-mediated src kinase but not PI 3-kinase signaling in pro T and pro B cell development. J. Exp. Med. 199, 867-878 https://doi.org/10.1084/jem.20031983
  2. Bischoff, S. C. 2007. Role of mast cells in allergic and non-allergic immune responses: Comparison of human and murine data. Nat. Rev. Immunol. 7, 93-104 https://doi.org/10.1038/nri2018
  3. Boesiger, J., M. Tsai, M. Maurer, M. Yamaguchi, L. F. Brown, K. P. Claffey, H. F. Dvorak and S. J. Galli. 1998. Mast cells can secrete vascular permeability factor/ vascular endothelial cell growth factor and exhibit enhanced release after immunoglobulin E-dependent upregulation of fc epsilon receptor I expression. J. Exp. Med. 188, 1135-1145 https://doi.org/10.1084/jem.188.6.1135
  4. Brown, J. M., T. M. Wilson and D. D. Metcalfe. 2008. The mast cell and allergic diseases: Role in pathogenesis and implications for therapy. Clin. Exp. Allergy 38, 4-18
  5. Bryce, P. J., M. L. Miller, I. Miyajima, M. Tsai, S. J. Galli and H. C. Oettgen. 2004. Immune sensitization in the skin is enhanced by antigen-independent effects of IgE. Immunity 20, 381-392 https://doi.org/10.1016/S1074-7613(04)00080-9
  6. Caron, G., Y. Delneste, E. Roelandts, C. Duez, J. Y. Bonnefoy, J. Pestel and P. Jeannin. 2001. Histamine polarizes human dendritic cells into Th2 cell-promoting effector dendritic cells. J. Immunol. 167, 3682-3686 https://doi.org/10.4049/jimmunol.167.7.3682
  7. Depinay, N., F. Hacini, W. Beghdadi, R. Peronet and S. Mecheri. 2006. Mast cell-dependent down-regulation of antigen-specific immune responses by mosquito bites. J. Immunol. 176, 4141-4146 https://doi.org/10.4049/jimmunol.176.7.4141
  8. Di Nardo, A., A. Vitiello and R. L. Gallo. 2003. Cutting edge: Mast cell antimicrobial activity is mediated by expression of cathelicidin antimicrobial peptide. J. Immunol. 170, 2274-2278 https://doi.org/10.4049/jimmunol.170.5.2274
  9. Echtenacher, B., D. N. Mannel and L. Hultner. 1996. Critical protective role of mast cells in a model of acute septic peritonitis. Nature 381, 75-77 https://doi.org/10.1038/381075a0
  10. Frandji, P., C. Tkaczyk, C. Oskeritzian, J. Lapeyre, R. Peronet, B. David, J. G. Guillet and S. Mecheri. 1995. Presentation of soluble antigens by mast cells: Upregulation by interleukin-4 and granulocyte/macrophage colony-stimulating factor and downregulation by interferon-gamma. Cell Immunol. 163, 37-46 https://doi.org/10.1006/cimm.1995.1096
  11. Furuta, T., T. Kikuchi, Y. Iwakura and N. Watanabe. 2006. Protective roles of mast cells and mast cell-derived TNF in murine malaria. J. Immunol. 177, 3294-3302 https://doi.org/10.4049/jimmunol.177.5.3294
  12. Galli, S. J., S. Nakae and M. Tsai. 2005. Mast cells in the development of adaptive immune responses. Nat. Immunol. 6, 135-142 https://doi.org/10.1038/ni1158
  13. Gilchrist, M., S. D. McCauley and A. D. Befus. 2004. Expression, localization, and regulation of NOS in human mast cell lines: Effects on leukotriene production. Blood 104, 462-469 https://doi.org/10.1182/blood-2003-08-2990
  14. Grimbaldeston, M. A., C. C. Chen, A. M. Piliponsky, M. Tsai, S. Y. Tam and S. J. Galli. 2005. Mast cell-deficient W-sash c-kit mutant kit W-sh/W-sh mice as a model for investigating mast cell biology in vivo. Am. J. Pathol. 167, 835-848 https://doi.org/10.1016/S0002-9440(10)62055-X
  15. Henz, B. M., M. Maurer, U. Lippert, M. Worm and M. Babina. 2001. Mast cells as initiators of immunity and host defense. Exp. Dermatol. 10, 1-10 https://doi.org/10.1034/j.1600-0625.2001.100101.x
  16. Huang, C., D. S. Friend, W. T. Qiu, G. W. Wong, G. Morales, J. Hunt and R. L. Stevens. 1998. Induction of a selective and persistent extravasation of neutrophils into the peritoneal cavity by tryptase mouse mast cell protease 6. J. Immunol. 160, 1910-1919
  17. Kashiwakura, J., H. Yokoi, H. Saito and Y. Okayama. 2004. T cell proliferation by direct cross-talk between OX40 ligand on human mast cells and OX40 on human T cells: Comparison of gene expression profiles between human tonsillar and lung-cultured mast cells. J. Immunol. 173, 5247-5257 https://doi.org/10.4049/jimmunol.173.8.5247
  18. Kitamura, Y., S. Go and K. Hatanaka. 1978. Decrease of mast cells in W/Wv mice and their increase by bone marrow transplantation. Blood 52, 447-452
  19. Knight, P. A., S. H. Wright, C. E. Lawrence, Y. Y. Paterson and H. R. Miller. 2000. Delayed expulsion of the nematode trichinella spiralis in mice lacking the mucosal mast cell-specific granule chymase, mouse mast cell protease-1. J. Exp. Med. 192, 1849-1856 https://doi.org/10.1084/jem.192.12.1849
  20. Lu, L. F., E. F. Lind, D. C. Gondek, K. A. Bennett, M. W. Gleeson, K. Pino-Lagos, Z. A. Scott, A. J. Coyle, J. L. Reed, J. Van Snick, T. B. Strom, X. X. Zheng and R. J. Noelle. 2006. Mast cells are essential intermediaries in regulatory T-cell tolerance. Nature 442, 997-1002 https://doi.org/10.1038/nature05010
  21. Malaviya, R. and S. N. Abraham. 2001. Mast cell modulation of immune responses to bacteria. Immunol. Rev. 179, 16-24 https://doi.org/10.1034/j.1600-065X.2001.790102.x
  22. Marshall, J. S. 2004. Mast-cell responses to pathogens. Nat. Rev. Immunol. 4, 787-799 https://doi.org/10.1038/nri1460
  23. Maurer, M., J. Wedemeyer, M. Metz, A. M. Piliponsky, K. Weller, D. Chatterjea, D. E. Clouthier, M. M. Yanagisawa, M. Tsai and S. J. Galli. 2004. Mast cells promote homeostasis by limiting endothelin-1-induced toxicity. Nature 432, 512-516 https://doi.org/10.1038/nature03085
  24. Maurer, M., S. Lopez Kostka, F. Siebenhaar, K. Moelle, M. Metz, J. Knop and E. von Stebut. 2006. Skin mast cells control T cell-dependent host defense in leishmania major infections. FASEB J. 20, 2460-2467 https://doi.org/10.1096/fj.06-5860com
  25. McDermott, J. R., R. E. Bartram, P. A. Knight, H. R. Miller, D. R. Garrod and R. K. Grencis. 2003. Mast cells disrupt epithelial barrier function during enteric nematode infection. Proc. Natl. Acad. Sci. U.S.A. 100, 7761-7766 https://doi.org/10.1073/pnas.1231488100
  26. McLachlan, J. B., J. P. Hart, S. V. Pizzo, C. P. Shelburne, H. F. Staats, M. D. Gunn and S. N. Abraham. 2003. Mast cell-derived tumor necrosis factor induces hypertrophy of draining lymph nodes during infection. Nat. Immunol. 4, 1199-1205 https://doi.org/10.1038/ni1005
  27. Metz, M., A. M. Piliponsky, C. C. Chen, V. Lammel, M. Abrink, G. Pejler, M. Tsai and S. J. Galli. 2006. Mast cells can enhance resistance to snake and honeybee venoms. Science 313, 526-530 https://doi.org/10.1126/science.1128877
  28. Metz, M. and M. Maurer. 2007. Mast cells--key effector cells in immune responses. Trends Immunol. 28, 234-241 https://doi.org/10.1016/j.it.2007.03.003
  29. Nakae, S., H. Suto, M. Iikura, M. Kakurai, J. D. Sedgwick, M. Tsai and S. J. Galli. 2006. Mast cells enhance T cell activation: Importance of mast cell costimulatory molecules and secreted TNF. J. Immunol. 176, 2238-2248 https://doi.org/10.4049/jimmunol.176.4.2238
  30. Ossovskaya, V. S. and N. W. Bunnett. 2004. Protease-activated receptors: Contribution to physiology and disease. Physiol. Rev. 84, 579-621 https://doi.org/10.1152/physrev.00028.2003
  31. Skokos, D., H. G. Botros, C. Demeure, J. Morin, R. Peronet, G. Birkenmeier, S. Boudaly and S. Mecheri. 2003. Mast cell-derived exosomes induce phenotypic and functional maturation of dendritic cells and elicit specific immune responses in vivo. J. Immunol. 170, 3037-3045 https://doi.org/10.4049/jimmunol.170.6.3037
  32. Stelekati, E., Z. Orinska and S. Bulfone-Paus. 2007. Mast cells in allergy: Innate instructors of adaptive responses. Immunobiology 212, 505-519 https://doi.org/10.1016/j.imbio.2007.03.012
  33. Tchougounova, E., A. Lundequist, I. Fajardo, J. O. Winberg, M. Abrink and G. Pejler. 2005. A key role for mast cell chymase in the activation of pro-matrix metalloprotease- 9 and pro-matrix metalloprotease-2. J. Biol. Chem. 280, 9291-9296 https://doi.org/10.1074/jbc.M410396200
  34. Vyas, H. and G. Krishnaswamy. 2006. Paul ehrlich's "mastzellen"--from aniline dyes to DNA chip arrays: A historical review of developments in mast cell research. Methods Mol. Biol. 315, 3-11
  35. Wanecek, M., E. Weitzberg, A. Rudehill and A. Oldner. 2000. The endothelin system in septic and endotoxin shock. Eur. J. Pharmacol. 407, 1-15 https://doi.org/10.1016/S0014-2999(00)00675-0
  36. Wang, H. W., N. Tedla, A. R. Lloyd, D. Wakefield and P. H. McNeil. 1998. Mast cell activation and migration to lymph nodes during induction of an immune response in mice. J. Clin. Invest. 102, 1617-1626 https://doi.org/10.1172/JCI3704
  37. Waskow, C., S. Paul, C. Haller, M. Gassmann and H. R. Rodewald. 2002. Viable c-kit (W/W) mutants reveal pivotal role for c-kit in the maintenance of lymphopoiesis. Immunity 17, 277-288 https://doi.org/10.1016/S1074-7613(02)00386-2
  38. Weber, A., J. Knop and M. Maurer. 2003. Pattern analysis of human cutaneous mast cell populations by total body surface mapping. Br. J. Dermatol. 148, 224-228 https://doi.org/10.1046/j.1365-2133.2003.05090.x
  39. Wolters, P. J., J. Mallen-St Clair, C. C. Lewis, S. A. Villalta, P. Baluk, D. J. Erle and G. H. Caughey. 2005. Tissue-selective mast cell reconstitution and differential lung gene expression in mast cell-deficient kit (W-sh)/Kit (W-sh) sash mice. Clin. Exp. Allergy 35, 82-88 https://doi.org/10.1111/j.1365-2222.2005.02136.x
  40. Wong, G. W., P. S. Foster, S. Yasuda, J. C. Qi, S. Mahalingam, E. A. Mellor, G. Katsoulotos, L. Li, J. A. Boyce, S. A. Krilis and R. L. Stevens. 2002. Biochemical and functional characterization of human transmembrane tryptase (TMT)/tryptase gamma. TMT is an exocytosed mast cell protease that induces airway hyperresponsiveness in vivo via an interleukin-13/interleukin-4 receptor alpha/signal transducer and activator of transcription (STAT) 6-dependent pathway. J. Biol. Chem. 277, 41906-41915 https://doi.org/10.1074/jbc.M205868200

Cited by

  1. Effects of the ethanol extract of Codonopsis Pilosulae Radix on ovalbumin-induced allergic responses in mice vol.28, pp.2, 2013, https://doi.org/10.6116/kjh.2013.28.2.9
  2. Anti-inflammatory Effect of Quercetin on Picryl Chloride-induced Contact Dermatitis in BALB/c Mice vol.26, pp.1, 2010, https://doi.org/10.5625/lar.2010.26.1.7