Korean Journal of Clinical Laboratory Science (대한임상검사과학회지)

Korean Society for Clinical Laboratory Science (대한임상검사과학회)
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A Cytogenetic Analysis of Abortus with Spontaneous Abortion

자연 유산 수태산물의 세포유전학적 분석

  • Oh, Hyun-Sook (Department of Clinical Laboratory Science, Wonkwang Health Science College) ;
  • Hwang, Si-Mok (Department of Clinical Laboratory Science, Wonkwang Health Science College) ;
  • Kwon, Kyung-Hun (Division of Research and Development, GenDix, Inc.)
  • 오현숙 (원광보건대학 임상병리과) ;
  • 황시목 (원광보건대학 임상병리과) ;
  • 권경훈 ((주)젠딕스 연구개발부)
  • Published : 2008.12.31
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Abstract

Chromosomal abnormalities of abortus have also been used to investigate the most common etiology of spontaneous abortion, but the frequency and the types of spontaneous abortions have also demonstrated considerable variation among in different countries and races. A cytogenetic analysis of 75 abortuses was performed at the GenDix, Inc. from January, 2006 to December, 2007. The frequency of chromosome abnormalities in abortus was 32.0% (24/75 cases). Among the chromosomal abnormalities, trisomy was 62.5% (15/24 cases) and the most frequent trisomy was trisomy 21 with 26.6% (4/15 cases). The average maternal age of normal and abnormal karyotypes was $34.1{\pm}3.3$ and $34.3{\pm}3.3$. Cytogenetic analysis of abortus is important for diagnosis and genetic counseling for parents with spontaneous abortion.

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