The Journal of Korean Physical Therapy
- 제20권3호
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- Pages.53-59
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- 2008
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- 1229-0475(pISSN)
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- 2287-156X(eISSN)
Endothelin-1-유도 근수축에 관여하는 부활효소의 활성과 물리치료의 상관성
The Activity of Protein Kinases on the Endothelin-1-induced Muscle Contraction and the relationship of Physical Therapy
- Kim, Mi-Sun (Department of Physical Therapy, the Graduate School, Doctoral Course, Yongin University) ;
- Kim, Il-Hyun (Department of Physical Therapy, the Graduate School of Rehabilitation and Health Science, Master Course, Yongin University) ;
- Hwang, Byong-Yong (Department of Physical Therapy, College of Health & Welfare, Yongin University) ;
- Kim, Jung-Hwan (Department of Physical Therapy, College of Health & Welfare, Yongin University)
- 발행 : 2008.09.25
초록
Purpose: The non-receptor-type protein tyrosine kinase Syk (636 amino acids, 72 kDa) is ubiquitously expressed in hematopoietic stem cells and has been widely studied as a regulator and effector of B cell receptor signaling that occurs in processes such as differentiation, proliferation and apoptosis. However, the mechanism relating Syk and p38 mitogen-activated protein kinases (p38MAPK) by endothelin-1 (ET-1, 21 amino acids) stimulation in muscle cells, especially in the volume-dependent hypertensive state, remains unclear. Methods: In this study, we investigated the relationship between Syk and p38MAPK for isometric contraction and enzymatic activity by ET-1 from rat aortic smooth muscle cells and aldosterone-analogue deoxycorticosterone acetate (DOCA) hypertensive state rats (ADHR). Results: The systolic blood pressure was significantly increased in ADHR than in a control group of animals. ET-1 induced isometric contraction and phosphorylation of p38MAPK, which was increased in muscle strips from ADHR. Increased vasoconstriction and phosphorylation of p38MAPK induced by treatment with 30 nM ET-1 were inhibited by the use of 10
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