The Journal of Korean Physical Therapy
- Volume 20 Issue 4
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- Pages.35-42
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- 2008
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- 1229-0475(pISSN)
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- 2287-156X(eISSN)
The Hypertensive Vascular Tension-related Signal Transduction and the Relationship of Physical Therapy
고혈압 혈관조직의 장력-연관 신호전달과 물리치료의 상관성
- Kim, Jung-Hwan (Department of Physical Therapy, College of Health & Welfare, Yongin University) ;
- Kim, Il-Hyun (Department of Physical Therapy, the Graduate School of Rehabilitation and Health Science, Master Course, Yongin University) ;
- Hwang, Byong-Yong (Department of Physical Therapy, College of Health & Welfare, Yongin University)
- Published : 2008.12.25
Abstract
Purpose: Alterations in the structure and function of vascular smooth muscle cells (VSMCs) are important in cardiovascular disease and maintaining chronic hypertension. Chronic hypertension is associated with changes in vascular smooth muscle tone. The spontaneous or myogenic tone of a blood vessel reflects the ability to adapt smooth muscle tone to changes in transmural pressure. However, the intracellular signaling mechanisms involved in myogenic tone are not fully understood. Methods: Here, we investigated the relationship between mitogen-activated protein kinases (MAPKs) and phosphatidylinositol-3 kinase (PI3K) in isometric contraction and enzymatic activity using muscle strips from rats made hypertensive with aldosterone-analogue deoxycorticosterone acetate (DOCA) salts. Results: Changes in myogenic tone and intracellular