Macromolecular Research

The Polymer Society of Korea (한국고분자학회)
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Alginate/Carboxymethyl Scleroglucan Hydrogels for Controlled Release of Protein Drugs

  • Lee, Chang-Moon (Department of Nuclear Medicine, Chonbuk National University Medical School, Research Institute of Clinical Medicine, Chonbuk National University Medical School, Institute for Medical Sciences, Chonbuk National University Medical School) ;
  • Jeong, Hwan-Jeong (Department of Nuclear Medicine, Chonbuk National University Medical School, Research Institute of Clinical Medicine, Chonbuk National University Medical School, Institute for Medical Sciences, Chonbuk National University Medical School) ;
  • Kim, Dong-Woon (Department of Clinical Pathology, Gwangyang Health College) ;
  • Lee, Ki-Young (Faculty of Applied Chemical Engineering and The Research Institute for Catalysis, Chonnam National University)
  • Published : 2008.07.31
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Abstract

Alginate/carboxymethyl scleroglucan (CMSG) hydrogels were suggested as a novel carrier for the controlled release of protein drugs. The drug release characteristics of alginate hydrogels were improved by CMSG addition. Scleroglucan (Sclg) was carboxymethylated using monochloroacetic acid in aqueous alkaline medium. Alginate/CMSG hydrogels were prepared by dropping the mixture solution of alginate/CMSG into calcium chloride solution. The swelling behaviors and drug release characteristics of the hydrogels were investigated in the buffers of pH 1.2 or 7.4. As the CMSG content increased in the hydrogels, the swelling ratio of the alginate/CMSG hydrogel increased rapidly in the buffer of pH 7.4. At pH 1.2, however, the swelling ratio significantly decreased compared to that at pH 7.4. According to in vitro release tests, only 15% of ovalbumin, investigated as a model protein drug, was released from the alginate/CMSG hydrogels at pH 1.2 within 6 h. At pH 7.4, however, the drug release significantly increased due to the rapid swelling of the hydrogels. The release and swelling behaviors of the hydrogels could be controlled by changing the CMSG content in the hydrogels. These results supported the use of alginate/CMSG hydrogels as a suitable carrier for the controlled release of protein drugs in a pH responsive manner.

Keywords

References

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