대한한방내과학회지 (The Journal of Internal Korean Medicine)
- 제29권3호
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- Pages.742-751
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- 2008
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- 1226-9174(pISSN)
삼자화담전(三子化痰煎)이 천식모델 생쥐의 면역세포에 미치는 영향
Effects of Samjawhadam-jeon on Immune Cells in Ovalbumin-induced Asthmatic Mice
- Lee, Joung-Eun (Division of Respiratory System, Dept. of Internal Medicine, College of Oriental Medicine, Daejeon University) ;
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Park, Yang-Chun
(Division of Respiratory System, Dept. of Internal Medicine, College of Oriental Medicine, Daejeon University)
- 발행 : 2008.09.30
초록
Objective: The purpose of this study was to evaluate the effect of Samjawhadam-jeon (SJHDJ; 三子化痰煎) on immune cells in OVA-induced asthmatic mice. Material and Methods : C57BL/6 mice were injected, inhaled and sprayed with OVA for 12 weeks (four times a week) for asthma induction. Two experimental groups were treated with different concentrations of SJHDJ group (400 mg/kg) extracts and cyclosporin A (10 mg/kg) for the latter 8 weeks. At the end of the experiment, the mouse lung. peripheral lymph node (PLN) and spleen were removed and immune cells were analyzed by flow cytometer. Results : Lung weight, total cells in lung, PLN, and spleen of the SJHDJ group decreased significantly compared with that of the control group. Number of