대한한방내과학회지 (The Journal of Internal Korean Medicine)

대한한방내과학회 (The Society of Internal Korean Medicine)
권호 표지

죽력(竹瀝)이 흰쥐의 중대뇌동맥(中大腦動脈) 및 전뇌허혈(全腦虛血) 폐쇄 허혈모델에 미치는 영향

Effect of Bambusae Caulis in Liquamen(Jukryuk) on Ischemic Damage to 4 Vessel Occlusion and Middle Cerebral Artery Occlusion in Mice

  • 김재홍 (경희대학교 한의과대학 2내과학교실) ;
  • 홍진우 (경희대학교 한의과대학 2내과학교실) ;
  • 나병조 (경희대학교 한의과대학 2내과학교실) ;
  • 박성욱 (경희대학교 한의과대학 2내과학교실) ;
  • 정우상 (경희대학교 한의과대학 2내과학교실) ;
  • 문상관 (경희대학교 한의과대학 2내과학교실) ;
  • 박정미 (경희대학교 한의과대학 2내과학교실) ;
  • 고창남 (경희대학교 한의과대학 2내과학교실) ;
  • 조기호 (경희대학교 한의과대학 2내과학교실) ;
  • 김영석 (경희대학교 한의과대학 2내과학교실) ;
  • 배형섭 (경희대학교 한의과대학 2내과학교실)
  • Kim, Jae-Hong (Department of Cardiovascular & Neurologic Diseases (Stroke Center), College of Oriental Medicine, Kyung Hee University) ;
  • Hong, Jin-Woo (Department of Cardiovascular & Neurologic Diseases (Stroke Center), College of Oriental Medicine, Kyung Hee University) ;
  • Na, Byung-Jo (Department of Cardiovascular & Neurologic Diseases (Stroke Center), College of Oriental Medicine, Kyung Hee University) ;
  • Park, Seong-Uk (Department of Cardiovascular & Neurologic Diseases (Stroke Center), College of Oriental Medicine, Kyung Hee University) ;
  • Jung, Woo-Sang (Department of Cardiovascular & Neurologic Diseases (Stroke Center), College of Oriental Medicine, Kyung Hee University) ;
  • Moon, Sang-Kwan (Department of Cardiovascular & Neurologic Diseases (Stroke Center), College of Oriental Medicine, Kyung Hee University) ;
  • Park, Jung-Mi (Department of Cardiovascular & Neurologic Diseases (Stroke Center), College of Oriental Medicine, Kyung Hee University) ;
  • Ko, Cham-Nam (Department of Cardiovascular & Neurologic Diseases (Stroke Center), College of Oriental Medicine, Kyung Hee University) ;
  • Cho, Ki-Ho (Department of Cardiovascular & Neurologic Diseases (Stroke Center), College of Oriental Medicine, Kyung Hee University) ;
  • Kim, Young-Suk (Department of Cardiovascular & Neurologic Diseases (Stroke Center), College of Oriental Medicine, Kyung Hee University) ;
  • Bae, Hyung-Sup (Department of Cardiovascular & Neurologic Diseases (Stroke Center), College of Oriental Medicine, Kyung Hee University)
  • 발행 : 2008.09.30
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초록

Objective : The purpose of this study was to investigate the neuroprotective effect of Jukryuk on 4-vessel occlusion(4-VO) and middle cerebral artery (MCA) ischemia. Method : After administration of Jukryuk, we compared the Jukryuk-treated group, the control, and the sham groups, in view of several points as follows 1) We evaluated the damage characterized by coagulative cell change of pyramidal neurons and pronounced gliosis in each group 2) We counted the number of normal pyramidal shapes after ischemia in each group 3) Immunohistochemistry (cyclooxygenase-2) 4) In focal ischemic injury model, we measured the volume of ischemic area Results : In this experiment, the effect of Jukryuk was determined to be protecting neuron cell shape, reducing the number of neuron cells damaged by ischemia and the volume of the ischemic area. In immunohistochemistry, Jukryuk reduced cyclooxygenase-2 expression Conclusions : According to this study, Jukryuk can protect neuron cells from injury by cerebrovascular ischemia.

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