대한한방내과학회지 (The Journal of Internal Korean Medicine)

대한한방내과학회 (The Society of Internal Korean Medicine)
권호 표지

생지황(生地黃)이 신절제술로 유도된 만성신부전 Rat에 미치는 영향(影響)

The Effects of Rehmannia on Nephrectomy-induced Chronic Renal Failure Rats

  • 최종배 (동신대학교 한의과대학 신계내과학교실) ;
  • 김용성 (동신대학교 한의과대학 신계내과학교실) ;
  • 한양희 (동신대학교 한의과대학 신계내과학교실)
  • Choe, Jong-Bae (Dept. of Internal Medicine, College of Oriental Medicine, Dongshin University) ;
  • Kim, Young-Seong (Dept. of Internal Medicine, College of Oriental Medicine, Dongshin University) ;
  • Han, Yang-Hee (Dept. of Internal Medicine, College of Oriental Medicine, Dongshin University)
  • 발행 : 2008.12.31
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초록

The aim of the study was to investigate recovery effects of Rehmannia, which has been used clinically for chronic renal failure therapy. Mice had 5/6 nephrectomy to induce chronic renal failure. The results were as follows: 1. The protein amount in urine per 24hrs of the Rehmannia-treated group was significantly reduced compared to the control. 2. The albumin amount in the blood of the Rehmannia-treated group significantly increased compared to the control. The creatinine. total-cholesterol, LDL-cholesterol and triglyceride levels in serum of the Rehmannia-treated group as compared to the control were significantly inhibited. 3. The structural change in kidney of the Rehrnannia-treated group was significantly inhibited compared to the control. 4. The factor (macrophage/monocyte antigen (ED-1), type IV collagen and angiotensin II type 1 ($AT_1$) receptor) of the Rehmanala-treated group was significantly inhibited compared to the control, which induced the structural change in kidneys. The above results suggest that Rehmannia partially improved kidney function.

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