The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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Comparative Study of Natural Killer Cell Activity after Red Ginseng Medication on Rat

원산지별 홍삼투여에 따른 백서의 자연살해세포 활성도 변화에 대한 연구

  • Im, Ju-Hyuk (Department of Oriental Internal Medicine, College of Oriental Medicine, Kyunghee University) ;
  • Cho, In-Young (Department of Oriental Internal Medicine, College of Oriental Medicine, Kyunghee University) ;
  • Min, Kyoung-Yoon (Department of Oriental Internal Medicine, College of Oriental Medicine, Kyunghee University) ;
  • Lee, Hae-Yong (Department of Oriental Internal Medicine, College of Oriental Medicine, Kyunghee University) ;
  • Kim, Seul-Ji (Department of Oriental Internal Medicine, College of Oriental Medicine, Kyunghee University) ;
  • Park, Young-Ju (Department of Oriental Internal Medicine, College of Oriental Medicine, Kyunghee University) ;
  • Lew, Jae-Hwan (Department of Oriental Internal Medicine, College of Oriental Medicine, Kyunghee University) ;
  • Lee, Beom-Joon (Department of Internal Medicine, Kangnam Korean Hospital, Kyunghee University) ;
  • Kim, Sung-Wook (Graduate School of East-West Medical Science, Kyunghee University) ;
  • Joo, Il-Woo (Graduate School of East-West Medical Science, Kyunghee University)
  • 임주혁 (경희대학교 한의과대학 내과학교실 동서협진실) ;
  • 조인영 (경희대학교 한의과대학 내과학교실 동서협진실) ;
  • 민경윤 (경희대학교 한의과대학 내과학교실 동서협진실) ;
  • 이혜영 (경희대학교 한의과대학 내과학교실 동서협진실) ;
  • 김슬지 (경희대학교 한의과대학 내과학교실 동서협진실) ;
  • 박영주 (경희대학교 한의과대학 내과학교실 동서협진실) ;
  • 류재환 (경희대학교 한의과대학 내과학교실 동서협진실) ;
  • 이범준 (경희대학교 강남한방병원 내상성인병센터) ;
  • 김성욱 (경희대학교 동서의학대학원) ;
  • 주일우 (경희대학교 동서의학대학원)
  • Published : 2008.12.31
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Abstract

Objectives : The purpose of this experiment is comparing the difference on natural killer cell activity through Korean red ginseng and Chinese red ginseng by $^{51}Cr$ release assay. Methods : Thirty rats were equally divided into a Korean red ginseng group, a Chinese red ginseng group and a control group. Korean and Chinese red ginseng were administrated to the rats at 200mg daily for a weak, while 0.9% normal saline was given to the control. Percent specific lysis (PSL) and lytic units (LU) were calculated from spleen cells by $^{51}Cr$ release assay. Results : Percent specific lysis of the Korean red ginseng group was significantly higher than that of the control in the ratio of 100:1, effector cell:target cell (p<0.05). Percent specific lysis of Korean red ginseng group was also significantly higher than that of the Chinese red ginseng group in the ratio of 25:1, effector cell:target cell (p<0.05). Chinese red ginseng showed no effect on NK cell activity. Conclusions : These findings suggest that Korean red ginseng improves immunologic function and shows superior effects than Chinese red ginseng.

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