대한한방내과학회지 (The Journal of Internal Korean Medicine)

대한한방내과학회 (The Society of Internal Korean Medicine)
권호 표지

택사 열수 및 에탄올 추출물의 항산화활성과 human LDL 산화억제 및 ACE 저해효과에 미치는 영향

Screening of Antioxidative, Anti-atherosclerotic Effect of Alisma Rhizome Extracts

  • 양영이 (동국대학교 한의과대학 MRC.진단학 교실) ;
  • 이민자 (동국대학교 한의과대학 MRC.진단학 교실) ;
  • 정현정 (동국대학교 한의과대학 MRC.진단학 교실) ;
  • 이혜숙 (동국대학교 한의과대학 MRC.진단학 교실) ;
  • 김혁 (동국대학교 한의과대학 MRC.진단학 교실) ;
  • 나선택 (동국대학교 한의과대학 MRC.진단학 교실) ;
  • 박선동 (동국대학교 한의과대학 방제학 교실) ;
  • 박원환 (동국대학교 한의과대학 MRC.진단학 교실)
  • Yang, Young-Yi (Cardiovascular Medical Research Center and Dept. of Diagnostics, College of Oriental Medicine, Dongguk University) ;
  • Lee, Min-Ja (Cardiovascular Medical Research Center and Dept. of Diagnostics, College of Oriental Medicine, Dongguk University) ;
  • Jung, Hyun-Jung (Cardiovascular Medical Research Center and Dept. of Diagnostics, College of Oriental Medicine, Dongguk University) ;
  • Lee, Hye-Sook (Cardiovascular Medical Research Center and Dept. of Diagnostics, College of Oriental Medicine, Dongguk University) ;
  • Kim, Hyuck (Cardiovascular Medical Research Center and Dept. of Diagnostics, College of Oriental Medicine, Dongguk University) ;
  • Na, Sun-Taek (Cardiovascular Medical Research Center and Dept. of Diagnostics, College of Oriental Medicine, Dongguk University) ;
  • Park, Sun-Dong (Dept. of Prescriptionology, College of Oriental Medicine, Dongguk University) ;
  • Park, Won-Hwan (Cardiovascular Medical Research Center and Dept. of Diagnostics, College of Oriental Medicine, Dongguk University)
  • 발행 : 2008.12.31
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초록

Objectives : The study was conducted to evaluate antioxidative, anti-atherosclerotic and anti-hypertensive effects of natural remedies. Alisma Rhizome (AR) has been used for a long time in Asia in folk remedies for treatment of hypertension and stroke and has been used in Korean traditional medicine for the treatment of glycosuria, gonorrhea, hypercholesterolemia, hypertension, and jaundice and its diuretic effect. These pharmacological effects of AR might come from antioxidant properties of phytochemicals in these materials. Methods : In this study, the antioxidant activity of extract from AR was studied with in vitro methods by measuring the antioxidant activity by TEAC, measuring the scavenging effects on reactive oxygen species (ROS) [superoxide anion, hydroxyl radical] and on reactive nitrogen species (RNS) [nitric oxide and peroxynitrite] as well as measuring the inhibitory effect on $Cu^{2+}$ induced human LDL oxidation and on ACE. Results : The AR extracts were found to have a potent scavenging activity, as well as an inhibitory effect on LDL oxidation and on ACE against all of the reactive species tested, with the water extract showing particularly strong antioxidant activities. Conculsions : The AR extracts have antioxidative, anti-atherosclerotic and anti-hypertensive effects in an in vitro system, which can be used for developing pharmaceutical drugs against oxidative stress and atherosclerosis.

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