대한한방내과학회지 (The Journal of Internal Korean Medicine)
- 제29권4호
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- Pages.835-845
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- 2008
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- 1226-9174(pISSN)
오미자(五味子)(Fructus Schisandrae)가 흰쥐 해마신경세포의 저산소증 모델에서 세포사에 미치는 영향
Prevention of ROS Production and MMP Dissipation by Fructus Schisandrae(FS) in a Hypoxic Model of Cultured Rat Hippocampal Neurons
- Ju, Dae-Hwan (Dept. of Oriental Internal Medicine, College of Oriental Medicine, Dongguk University) ;
- Shin, Gil-Cho (Dept. of Oriental Internal Medicine, College of Oriental Medicine, Dongguk University) ;
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Moon, Il-Soo
(Dept. of Anatomy, College of Medicine, Dongguk University)
- 발행 : 2008.12.31
초록
Objectives : The purpose of this study was to investigate the effect of FS for the modulation of ROS and MMP in a hypoxic model of cultured rat cortical cells. Methods : For the effect of FS on the viability, FS was added to culture media (neurobasal supplemented with B27) and cell viability was measured by LDH assay. To investigate the effects of FS on ROS generation and MMP preservation, cells grown in FS-containing media were given a hypoxic shock(2%