Advances in Traditional Medicine

Kyung Hee Oriental Medicine Research Center (경희대학교 융합한의과학연구소)
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Cytotoxicity and antinociceptive activity of Jasminum sambac leaves

  • Islam, Md Rahatul (Pharmacy Discipline, Life Science School, Khulna University) ;
  • Rouf, Razina (Pharmacy Discipline, Life Science School, Khulna University) ;
  • Barua, Juwel (Pharmacy Discipline, Life Science School, Khulna University) ;
  • Uddin, Shaikh Jamal (Pharmacy Discipline, Life Science School, Khulna University) ;
  • Alamgir, Mahiuddin (School of Chemistry, University of New South Wales)
  • Published : 2008.06.30
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Abstract

The ethanolic extract of Jasminum sambac leaves were tested for its cytotoxicity and possible antinociceptive activity in experimental animals. The extract showed potent cytotoxic activity in brine shrimp lethality assay and the LC50 was found only 25 mg/ml. The extract significantly and dose dependently inhibited the acetic acid induced writhing in mice (56.83%, P < 0.001 and 43.17%, P < 0.001 for 500 and 250 mg/kg body weight, respectively). The results supported its traditional uses.

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References

  1. Ghani A. (2003) Medicinal Plants of Bangladesh. Asiatic Society of Bangladesh, Dhaka
  2. Junji I, Naoharu W, Jae-Hak M, Akihito Y, Kanzo S, Kazuo I, Shaojun L. (1995) Glycosidic aroma precursors of 2-phenylethyl and benzyl alcohols from Jasminum sambac flowers. Biosci. Biotechnol. Biochem. 59, 738-739
  3. Meyer BN, Ferrigni NR, Putnam JB, Jacobsen LB, Nichols DE, McLaughlin JL. (1982) Brine shrimp: a convenient general bioassay for active plant constituents. Planta Med. 45, 31-34 https://doi.org/10.1055/s-2007-971236
  4. Shilpi JA, Uddin SJ, Rouf R, Billah MM. (2004) Central nervous system depressant activity of Diospyros peregrina bark. Orient. Pharm. Exp. Med. 4, 249-252
  5. Uddin SJ, Shilpi JA, Alam SMS, Alamgir M, Rahman MT, Sarker SD. (2005) Antidiarrhoeal activity of the methanol extract of the barks of Xylocarpus molucensis in castor oil and magnesium sulphateinduced diarrhoea models in mice. J Ethnopharmacol 101, 139-143 https://doi.org/10.1016/j.jep.2005.04.006
  6. Uddin SJ, Shilpi JA, Barua J, Rouf R. (2005) Antinociceptive activity of Ceriops decandra leaf and pneumatophore. Fitoterapia 76, 261-263 https://doi.org/10.1016/j.fitote.2004.12.015
  7. Uddin SJ, Shilpi JA, Delazar A, Nahar L, Sarker SD. (2004) Free radical scavenging activity of some Bangladeshi plant extracts. Orient. Pharm. Exp. Med. 4, 185-193