Journal of Yeungnam Medical Science

Yeungnam University College of Medicine, Yeungnam University Institute Medical Science (영남대 의대 학술지 편집위원회)
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A Case of Dermatomyositis with Secondary Organizing Pneumonia

이차성 기질화 폐렴이 동반된 피부근염 1예

  • Park, Chul-Yun (Department of Internal Medicine, School of Medicine, Catholic University of Daegu) ;
  • Chung, Jung-Seok (Department of Internal Medicine, School of Medicine, Catholic University of Daegu) ;
  • Chung, Jin-Wook (Department of Internal Medicine, School of Medicine, Catholic University of Daegu) ;
  • Lee, Choong-Ki (Deparment of Internal Medicine, College of Medicine, Yeungnam University) ;
  • Hyun, Dae-Sung (Department of Internal Medicine, School of Medicine, Catholic University of Daegu) ;
  • Choe, Jung-Yoon (Department of Internal Medicine, School of Medicine, Catholic University of Daegu)
  • 박철연 (대구가톨릭대학교 의과대학 내과학교실) ;
  • 권정석 (대구가톨릭대학교 의과대학 내과학교실) ;
  • 정진욱 (대구가톨릭대학교 의과대학 내과학교실) ;
  • 이충기 (영남대학교 의과대학 내과학교실) ;
  • 현대성 (대구가톨릭대학교 의과대학 내과학교실) ;
  • 최정윤 (대구가톨릭대학교 의과대학 내과학교실)
  • Published : 2008.12.30
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Abstract

Dermatomyositis is characterized by progressive, symmetric, proximal muscle weakness and a nonsuppurative inflammatory myopathy of unknown etiology involving predominantly skeletal muscles. It is also characterized by typical skin lesions. Interstitial lung disease has a poor prognosis when it is associated with dermatomyositis. Organizing pneumonia is a disease in which granulation tissue fills the lumina of terminal and respiratory bronchioles and extends into the distal airspaces. The cryptogenic nature of the process is appreciated in that organizing pneumonia patterns of injury can be seen in secondary forms of the disease (secondary organizing pneumonia). Organizing pneumonia has been reported to occur in 5~10% in dermatomyositis-polymyositis patients. Anti-histidyl tRNA synthetase antibody (anti-Jo-1) is a predictive disease marker that is reported to occur in up to 70% of patients. We describe a 49-year-old male dermatomyositis patient who presented with organizing pneumonia and was found to have negative anti-Jo-1 antibody.

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