Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Inhibitory Effect Against Akt by Cyclic Dipeptides Isolated from Bacillus sp.

  • Hong, Sung-Won (Bio/Molecular Informatics Center, Division of Bioscience and Biotechnology, Konkuk University) ;
  • Moon, Byoung-Ho (Bio/Molecular Informatics Center, Division of Bioscience and Biotechnology, Konkuk University) ;
  • Yong, Yeon-Joong (Bio/Molecular Informatics Center, Division of Bioscience and Biotechnology, Konkuk University) ;
  • Shin, Soon-Young (Institute of Biomedical Science and Technology, Konkuk University) ;
  • Lee, Young-Han (Institute of Biomedical Science and Technology, Konkuk University) ;
  • Lim, Yoong-Ho (Bio/Molecular Informatics Center, Division of Bioscience and Biotechnology, Konkuk University)
  • Published : 2008.04.30
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Abstract

Among thirteen strains of the genus Bacillus isolated from Shrimp-jeotkal in our laboratory, a strain BA34 showing good antifungal activity against Phytophthora infestans in a previous experiment was tested for the inhibitory effect against Akt, protein kinase B. Since Akt is known to play an important role in controlling apoptosis, its inhibitors can be used as potential apoptosis-inducing agents in the treatment of cancer. Two active compounds were isolated and their structures were determined. They have similar structures, despite showing different inhibitory effects. In order to elucidate the reasons for these different effects, three-dimensional studies were carried out.

Keywords

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