The Journal of Korean Medicine (대한한의학회지)
- Volume 29 Issue 2
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- Pages.7-20
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- 2008
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- 1010-0695(pISSN)
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- 2288-3339(eISSN)
Effects of Kamijihwang-tang on Immune Cells and Cytokines in OVA-induced Asthmatic Mice
가미지황탕(加味地黃湯)이 천식모델 생쥐의 면역세포 및 사이토카인에 미치는 영향
- Rah, Do-Gyun (Division of Respiratory System, Dept. of Internal Medicine, College of Oriental Medicine, Daejeon University) ;
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Park, Yang-Chun
(Division of Respiratory System, Dept. of Internal Medicine, College of Oriental Medicine, Daejeon University)
- Published : 2008.06.30
Abstract
Objectives: The purpose of this study wasto examine the effects of Kamijihwang-tang (KJHT) extracts on immune cells and cytokines in ovalbumin (OVA)-induced asthmatic mice. Methods: C57BL/6 mice were injected, inhaled and sprayed with OVA for 12 weeks (four times a week) for asthma induction. Two experimental groups were treated with different concentrations of KJHT (400 mg/kg and 200 mg/kg) extracts and cyclosporine A (10 mg/kg) for the later 8 weeks. At the end of the experiment, the mice lung, PLN and spleen were removed and immune cells were analyzed by flow cytometer, IL-5, IL-13, eotaxin-2,