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스트레스에 대한 고려 인삼의 효능

Effects of Panax ginseng on Stress

  • 발행 : 2008.03.31

초록

스트레스 반응은 위급 상황에서만 활성화 되는 것이 아니라 우리 주변을 둘러싼 모든 사회적, 물리적 환경에 의해 끊임없이 기인된다. 예를 들어 소음, 강한 빛과 열, 주거의 공간 등과 같은 물리적 환경과 타인과의 관계, 부당한 대우, 규칙, 형식과 같은 사회적 관계 이 그것이다. 고려 인삼은 항스트레스 작용을 한다고 알려져 있으나 현재까지 대부분의 연구는 인삼 엑기스 또는 총 사포닌을 투여 시 나타나는 물리화학적인 척도 (수영 시간, 뜨거움에 대한 반응, 포도당 및호르몬 수준 등)를 측정하였으며 뇌에서 ginsenoside의 기능연구는 매우 미흡한 수준이다. 특히 신호전달, 전사체 (transcriptome),proteomics, system biology와 같은 분자생물학적인 방법을 이용한 기전 연구는 전혀 수행된 바 없다. 따라서 인삼의 항 스트레스 반응 기전을 이해하기 위해서는 인삼투여 후 뇌에서 나타나는 분자적 변화에 대한 연구가 앞으로 요구된다. 또한 microarray 등의 분자생물학적 기법을 이용하여 인삼 투여에 의해 반응하는 유전자를 발굴함으로써 이러한 인자들이 인삼 효능 시험 등에 지표로 응용될 수 있을것이다.

Stress activates hypothalamic-pituitary-adrenal (HPA) axis and subsequently increases the systemic levels of glucocorticoids. It also inhibits the release of gonadotropin-releasing hormone (GnRH) from hypothalamus. Korean ginseng (Panax ginseng CA Meyer) has been proven as an anti-stress agent. However, most of the anti-stress effects of ginseng on stresses such as immobilization, electronic foot shock, and cold swim, which subsequently cause oxidative damage in brain, were obtained by using ginseng extract or ginseng total saponin. Moreover, anti-stress and anti-oxidative effects of ginseng were demonstrated by determination of enzyme or hormone levels but not mRNA as well as transcriptome. Further studies on transcriptome, proteomics, and systems biology as well as signal transduction would be required to elucidate molecular action mechanisms of ginseng on stresses.

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참고문헌

  1. Ha, D. C. and Ryu, G. H. : Chemical components of red, white and extruded root ginseng. J. Korea Soc. Food Sci. Nutr. 34, 247-254 (2005). https://doi.org/10.3746/jkfn.2005.34.2.247
  2. Park, C. K., Jeon, B. S. and Yang, J. W. : The chemical components of Korean Ginseng. Food Industry and Nutrition 8, 10-24 (2003).
  3. Choi, M., Shin, G. J., Choi, G. P., Do, J. H. and Kim, J. D. : Synergistic effects of extracts from Korean red ginseng, saururus chinensis (Lour.) Baill and Rubus coreanus Miq on antioxidative activities in rats. Korean J. Medical Crop Sci. 14, 27-30 (2003).
  4. Han, B. H., Park, M. H. and Wee, J. J. : Studies on antioxidant components of Korean ginseng (V). The mechanism of antioxidant activity of maltol and phenolic acid. Korean Biochem. J. 18, 337-340 (1985).
  5. Lee, S. E., Lee, S. W., Bang, J. K., Yu, Y. J. and Seong, N. S. : Antioxidant activities of leaf, stem, and root of panax ginseng C. A. Meyer. Korean J. Medicinal Crop Sci. 12, 237-242 (2001).
  6. Brekhman II, Dardymov IV. : New substances of plant origin which increase nonspecific resistance. Annu. Rev. Pharmacol. Toxicol. 9, 419-439 (1969). https://doi.org/10.1146/annurev.pa.09.040169.002223
  7. Kim, S. H., Park, K. S., Chang, M. J. and Sung, J. H. : Effects of Panax ginseng extract on exercise-induced oxidative stress. J. Sports. Med. Phys. Fitness. 45, 178-182 (2005).
  8. Voces, J., Cabral, de Oliveira A. C., Prieto, J. G., Vila L., Perez, A. C., Duarte, I. D. and Alvarez, A. : Ginseng administration protects skeletal muscle from oxidative stress induced by acute exercise in rats. Braz. J. Med.Biol. Res. 37, 1863-71 (2004).
  9. Pannacci, M., Lucini, V., Colleoni, F., Martucci, C., Grosso, S., Sacerdote, P. and Scaglione, F. : Panax ginseng C.A. Mayer G115 modulates pro-inflammatory cytokine production in mice throughout the increase of macrophage toll-like receptor 4 expression during physical stress. Brain Behav. Immun. 20, 546-51 (2006). https://doi.org/10.1016/j.bbi.2005.11.007
  10. Luo, Y. M., Cheng, X. J. and Yuan, W. X. : Effects of ginseng root saponins and ginsenoside Rb1 on immunity in cold water swim stress mice and rats. Zhongguo Yao Li Xue Bao. 14, 401-404 (1993).
  11. Choi, S. S., Lee, J. K. and Suh, H. W. : Effect of ginsenosides administered intrathecally on the antinociception induced by cold water swimming stress in the mouse, Biol Pharm Bull. 26, 858-861 (2003). https://doi.org/10.1248/bpb.26.858
  12. Chen, J. X., Li, W., Zhao, X. and Yang, J. X. : Effects of the Chinese traditional prescription xiaoyaosan decoction on chronic immobilization stress-induced changes in behavior and brain BDNF, TrkB, and NT-3 in rats. Cell. Mol. Neurobiol. (2007).
  13. Johnson, E. O., Kamilaris, T. C., Chrousos, G. P. and Gold, P. W. : Mechanisms of stress: a dynamic overview of hormonal and behavioral homeostasis. Neurosci. Biobehav. Rev. 16, 115-130 (1992). https://doi.org/10.1016/S0149-7634(05)80175-7
  14. Selye, H. : Stress in health and disease. Boston: Butterworth (1976).
  15. 민병일: 스트레스 과학의 이해; 스트레스와 생리. 신광출판사 (1997).
  16. 정현숙, 강규숙, 황애란: 정신 사회적 스트레스와 스트레스질 환. 대한간호학회지, 26, 25-28 (1998).
  17. 은희관: 인지적 통제불능 스트레스 후 대처방안이 호르몬 회 복 및 운동 수행력 변화에 미치는 영향. 박사학위 논문. 한 양대 (1992).
  18. 김의진: 언론인의 규칙적인 운동수행이 마감스트레스에 미치 는 영향. 박사학위 논문. 성균관대 (2004).
  19. 고선영: Type D 성격 유형과 급성스트레스에 따른 자율신경 계 반응. 성신여대 석사학위 논문 (2006).
  20. Pacák, K. and Palkovits, M. : Stressor specificity of central neuroendocrine responses: implications for stress-related disorders. Endocr. Rev. 22, 502-548 (2001). https://doi.org/10.1210/er.22.4.502
  21. Kovács, P., Juránek, I., Stankovicová, T. and Svec, P.: Lipid peroxidation during acute stress. Pharmazie 51, 51-53 (1996).
  22. Liu, J., Wang, X., Shigenaga, M. K., Yeo, H. C., Mori, A. and Ames, B. N.: Immobilization stress causes oxidative damage to lipid, protein, and DNA in the brain of rats. FASEB J. 10, 1532-1538 (1996). https://doi.org/10.1096/fasebj.10.13.8940299
  23. Shaheen, A. A., Abd El-Fattah A. and Gad, M. Z.: Effect of various stressors on the level of lipid peroxide, antioxidants and Na+, K(+)-ATPase activity in rat brain. Experientia 52, 336-339 (1996). https://doi.org/10.1007/BF01919536
  24. Rhyu, D. Y., Kang, K. S., Sekiya, M. and Yokozawa, T. : Antioxidant effect of Wen-Pi-Tang and its component crude drugs on oxidative stress. Am. J. Chin. Med. 35, 127-137 (2007). https://doi.org/10.1142/S0192415X07004680
  25. Wang, C. Z., Aung, H. H., Ni, M., Wu, J. A., Tong, R., Wicks, S., He, T. C. and Yuan, C. S. : Red American ginseng: ginsenoside constituents and antiproliferative activities of heatprocessed Panax quinquefolius roots. Planta Med. 73, 669- 674 (2007). https://doi.org/10.1055/s-2007-981524
  26. Yao, H. T., Chang, Y. W., Chen, C. T., Chiang, M. T., Chang, L. and Yeh, T. K. : Shengmai San reduces hepatic lipids and lipid peroxidation in rats fed on a high-cholesterol diet. J. Ethnopharmacol. 116, 49-57 (2008). https://doi.org/10.1016/j.jep.2007.10.043
  27. Chang, H. F., Lin, Y. H., Chu, C. C., Wu, S. J., Tsai, Y. H. and Chao, J. C. : Protective Effects of Ginkgo biloba, Panax ginseng, and Schizandra chinensis Extract on Liver Injury in Rats. Am. J. Chin. Med. 35, 995-1009 (2007). https://doi.org/10.1142/S0192415X07005466
  28. Kim, J. W. and Kirkpatrick, B. : Social isolation in animal models of relevance to neuropsychiatric disorders. Biol. Psychiatry 40, 918-922 (1996). https://doi.org/10.1016/0006-3223(95)00546-3
  29. Pashko, S., DeTurck, K. H. and Vogel, W. H. : Use of the catheterized rat in studies on social interactions and plasma catecholamines. Pharmacol. Biochem. Behav. 13, 471-473 (1980). https://doi.org/10.1016/0091-3057(80)90258-0
  30. Weiss, I. C., Pryce, C. R., Jongen-Rêlo, A. L., Nanz-Bahr, N. I. and Feldon, J. : Effect of social isolation on stress-related behavioural and neuroendocrine state in the rat. Behav. Brain Res. 152, 279-295 (2004). https://doi.org/10.1016/j.bbr.2003.10.015
  31. Kaneko, H. and Nakanishi, K. : Proof of the mysterious efficacy of ginseng: basic and clinical trials: clinical effects of medical ginseng, Korean red ginseng: specifically, its antistress action for prevention of disease. J. Pharmacol. Sci. 95, 158-162 (2004). https://doi.org/10.1254/jphs.FMJ04001X5
  32. Iwasaka, H. : Examination of fatigue of an anesthesiologist. Operation Region Medicine 13, 119-121 (1992).
  33. Taylor, N.L., Millar, A.H.: Oxidative stress and plant mitochondria. Mol. Biol. 372, 389-403 (2007).
  34. 이점옥, 류승희, 이유순, 김정인, 문갑순.: Streptozotocin-유발 당뇨쥐에서 부추식이의 산화적 스트레스 및 Lipofuscin 생성 억제 효과. 한국식품영향과학회지. 32, 1337-1343 (2003).
  35. 박수남. : 천연물의 피부세포에 미치는 영향; 활성산호의 작용과 억제. 대한화장품학회지 25, 77-127 (1999).
  36. López, M. V., Cuadrado, M. P., Ruiz-Poveda, O. M., Del Fresno A. M. and Accame M. E. : Neuroprotective effect of individual ginsenosides on astrocytes primary culture. Biochim. Biophys. Acta 1770, 1308-16 (2007). https://doi.org/10.1016/j.bbagen.2007.06.008
  37. Zhang, Q. H., Wu, C. F., Duan, L. and Yang, J. Y. : Protective effects of total saponins from stem and leaf of Panax ginseng against cyclophosphamide-induced genotoxicity and apoptosis in mouse bone marrow cells and peripheral lymphocyte cells. Food Chem. Toxicol. 46, 293-302 (2008). https://doi.org/10.1016/j.fct.2007.08.025
  38. Cho, W. C., Yip, T. T., Chung, W. S., Lee, S. K., Leung, A. W., Cheng, C. H. and Yue, K. K.: Altered expression of serum protein in ginsenoside Re-treated diabetic rats detected by SELDI-TOF MS. J. Ethnopharmacol. 108, 272-279 (2006). https://doi.org/10.1016/j.jep.2006.05.009
  39. Pacak, K., Palkovits, M., Makino, S., Kopin, I. J. and Goldstein, D. S. : Brainstem hemisection decreases corticotropin- releasing hormone mRNA in the paraventricular nucleus but not in the central amygdaloid nucleus. J. Neuroendocrinol. 8, 543-551 (1996). https://doi.org/10.1046/j.1365-2826.1996.04888.x
  40. Lee, S. H., Jung, B. H., Kim, S. Y., Lee, E. H. and Chung, B. C. : The anti stress effect of ginseng total saponin and ginsenoside Rg3 and Rb1 evaluated by brain polyamine level under immobilization stress. Pharmacol. Res. 54, 46- 49 (2006). https://doi.org/10.1016/j.phrs.2006.02.001
  41. Kim, D. H., Moon, Y. S., Lee, T. H., Jung, J. S., Suh, H. W. and Song, D. K. : The inhibitory effect of ginseng saponins on the stress-induced plasma interleukin-6 level in mice. Neurosci. Lett. 15, 353(1), 13-16 (2003).
  42. Rai, D., Bhatia, G., Sen, T. and Palit, G. : Anti-stress effects of Ginkgo biloba and Panax ginseng: a comparative study. J. Pharmacol. Sci. 93, 458-464 (2003). https://doi.org/10.1254/jphs.93.458

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  1. Revitalizing Mountain Ginseng Cultivation in North Jeolla Province, South Korea vol.15, pp.4, 2016, https://doi.org/10.1007/s11842-016-9336-z
  2. Protective effects of red ginseng according to steaming time on HCl/ethanol-induced acute gastritis vol.59, pp.4, 2016, https://doi.org/10.3839/jabc.2016.062
  3. Quality Characteristics of 4 Year-old Ginseng by Enzymatic Hydrolysis Conditions vol.40, pp.2, 2011, https://doi.org/10.3746/jkfn.2011.40.2.229