The Journal of Korean Obstetrics and Gynecology (대한한방부인과학회지)
- Volume 21 Issue 1
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- Pages.117-133
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- 2008
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- 1229-4292(pISSN)
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- 2508-3619(eISSN)
The Experimental Study on Anti-thrombotic Effect of Hyulbuchukeotanggamibang(HBCT)
혈부축어탕가미방(血府逐瘀湯加味方)의 항혈전작용(抗血栓作用)에 대한 실험적(實驗的) 연구(硏究)
- Lim, Hyun-Jung (Dept. of Oriental Medicine Graduate School, Daejeon University) ;
- Shin, Sun-Mi (Dept. of Oriental Medicine Graduate School, Daejeon University) ;
- Kim, Soo-Min (Dept. of Oriental Medicine Graduate School, Daejeon University) ;
- Lee, Jung-Eun (Dept. of Oriental Medicine Graduate School, Daejeon University) ;
- Yoo, Dong-Youl (Dept. of Oriental Medicine Graduate School, Daejeon University)
- 임현정 (대전대학교 한의과대학 부인과교실) ;
- 신선미 (대전대학교 한의과대학 부인과교실) ;
- 김수민 (대전대학교 한의과대학 부인과교실) ;
- 이정은 (대전대학교 한의과대학 부인과교실) ;
- 유동열 (대전대학교 한의과대학 부인과교실)
- Published : 2008.02.29
Abstract
Purpose: This study was performed to evaluate anti-thrombotic effects of Hyulbuchukeotanggamibang(HBCT). Methods: It was measured the effects which was given to blood flow rate through the regular volume of glass tube after the blood was diluted five times with ACD soulution. Antithrombotic effect was calculated as a percentage of the experimental animal figure protected from the paralysis of hind legs or death of the mouse that is caused from the administration of platelet aggregation regent. Results: 1. HBCT showed a safety in toxicity of liver. 2. In experiment of anti-thrombotic effect, HBCT inhibited the platelet aggregation induced by ADP and epinephrine, collagen, arachidonic acid as compared with the control group. 3. HBCT inhibited pulmonary embolism induced by collagen and epinephrine (inhibitory rate is 50%). 4. HBCT increased platelet number and fibrinogen amount significantly and also HBCT shortened PT and APTT significantly as compared with the control group in thrombus model induced by dextran. 5. HBCT increased blood flow rate insignificantly as compared with the control group in vivo. Conclusion: These results suggest that HBCT can be used for treating diverse female diseases caused by thrombosis.