Biomolecules & Therapeutics

  • 제16권1호
  • /
  • Pages.46-53
  • /
  • 2008
  • /
  • 1976-9148(pISSN)
  • /
  • 2005-4483(eISSN)
한국응용약물학회 (The Korean Society of Applied Pharmacology)
권호 표지
DOI QR코드

DOI QR Code

Hypolipidemic and Hepatoprotecitive Effects of Picrorrhiza Rhizoma in High Fat Diet Supplied Mice. A Pevention Sudy.

  • Lee, Hyeung-Sik (Department of Herbal Biotechnology, Daegu Haany University) ;
  • Woo, Sung-Jung (Department of Herbal Biotechnology, Daegu Haany University) ;
  • Ku, Sae-Kwang (Department of Anatomy and Histology, College of Oriental Medicine, Daegu Haany University, Development Team for The New Drug of Oriental Medicine (BK21 program), Daegu Haany University)
  • 발행 : 2008.03.28
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

The preventive hypolipidemic effect of the aqueous extracts of Picrorrhiza Rhizoma (PR) was observed in a high fat diet (HFD) feeding hyperlipidemic mouse with their hepatoprotective effects. PR extracts (50, 100 and 200mg/kg) were orally dosed once a day for 12 weeks initiated with HFD supply, and changes on body weight and gains, liver weight, serum aspartate transferase (AST) and alanine transferase (ALT) levels were monitored with serum low density lipoprotein (LDL), high density lipoprotein (HDL), triglyceride and total cholesterol levels. The efficacy of test articles was compared to that of 10mg/kg of simvastatin (SIMVA). Dramatic decrease of both absolute and relative liver weight was dose-dependently observed in all PR extract dosing groups as compared with HFD control group. The serum AST and ALT levels were dose-dependently decreased in PR extract dosing groups. The serum LDL, triglyceride and total cholesterol levels were dose-dependently decreased in PR extract dosing groups compared to that of HFD control group. The serum HDL levels were slightly but dose-dependently increased in PR extract dosing groups as compared with control group. The efficacy on the serum lipid levels of PR extracts was slighter than that of SIMVA. Based on these results, it is concluded that water extract of PR has a relatively good favorable preventive effects on the HFD inducing hyperlipidemia and hepatopathy.

키워드

참고문헌

  1. Bhandari, U., Kanojia, R. and Pillai, K.K. (2002). Effect of ethanolic extract of Embelia ribes on dyslipidemia in diabetic rats. Int. J. Exp. Diabetes Res. 3, 159-162 https://doi.org/10.1080/15604280214278
  2. Ble-Castillo, J.L., Rodriguez-Hernandez, A., Miranda-Zamora, R., Juarez-Oropeza, M.A. and Diaz-Zagoya, J.C. (2002). Arthrospira maxima prevents the acute fatty liver induced by the administration of simvastatin, ethanol and a hypercholesterolemic diet to mice. Life Sci. 70, 2665-2673 https://doi.org/10.1016/S0024-3205(02)01512-6
  3. Cheng, J.W. (2004) Rosuvastatin in the management of hyperlipidemia. Clin. Ther. 26, 1368-1387 https://doi.org/10.1016/j.clinthera.2004.09.005
  4. Dimo, T., Rakotonirina, S.V., Tan, P.V., Azay, J., Dongo, E. and Cros, G. (2002). Leaf methanol extract of Bidens pilosa prevents and attenuates the hypertension induced by high-fructose diet in Wistar rats. J. Ethnopharmacol. 83, 183-191 https://doi.org/10.1016/S0378-8741(02)00162-9
  5. el-Saadany, S.S., el-Massry, R.A., Labib, S.M. and Sitohy, M.Z. (1991). The biochemical role and hypocholesterolaemic potential of the legume Cassia fistula in hypercholesterolaemic rats. Nahrung 35, 807-815 https://doi.org/10.1002/food.19910350804
  6. Forrester, J.S., Makkar, R. and Shah, P.K. (2005). Increasing high-density lipoprotein cholesterol in dyslipidemia by cholesteryl ester transfer protein inhibition: an update for clinicians. Circulation, 111, 1847-1854 https://doi.org/10.1161/01.CIR.0000160860.36911.BD
  7. Grundy, S.M. (1986). Cholesterol and coronary heart disease: a new era. J. Am. Med. Assoc. 256, 2849-2858 https://doi.org/10.1001/jama.256.20.2849
  8. Han, L.K., Zheng, Y.N., Yoshikawa, M., Okuda, H. and Kimura, Y. (2005). Anti-obesity effects of chikusetsusaponins isolated from Panax japonicus rhizomes. BMC Complement Altern. Med. 5, 9 https://doi.org/10.1186/1472-6882-5-9
  9. Herrera-Arellano, A., Aguilar-Santamaria, L., Garcia-Hernandez, B., Nicasio-Torres, P. and Tortoriello, J. (2004). Clinical trial of Cecropia obtusifolia and Marrubium vulgare leaf extracts on blood glucose and serum lipids in type 2 diabetics. Phytomedicine 11, 561-566 https://doi.org/10.1016/j.phymed.2004.01.006
  10. Hoyos, M., Guerrero, J.M., Perez-Cano, R., Olivan, J., Fabiani, F., Garcia-Perganeda, A. and Osuna, C. (2000). Serum cholesterol and lipid peroxidation are decreased by melatonin in diet-induced hypercholesterolemic rats. J. Pineal Res. 28, 150-155 https://doi.org/10.1034/j.1600-079X.2001.280304.x
  11. Jagetia, G.C. and Baliga, M.S. (2004). The evaluation of nitric oxide scavenging activity of certain Indian medicinal plants in vitro: a preliminary study. J. Med. Food 7, 343-348 https://doi.org/10.1089/jmf.2004.7.343
  12. Jeena, K.J., Joy, K.L. and Kuttan, R. (1999). Effect of Emblica officinalis, Phyllanthus amarus and Picrorrhiza kurroa on N-nitrosodiethylamine induced hepatocarcinogenesis. Cancer Lett. 136, 11-16 https://doi.org/10.1016/S0304-3835(98)00294-8
  13. Joy, K.L. and Kuttan, R. (1999). Anti-diabetic activity of Picrorrhiza kurroa extract. J. Ethnopharmacol. 67, 143- 148 https://doi.org/10.1016/S0378-8741(98)00243-8
  14. Joy, K.L., Rajeshkumar, N.V., Kuttan, G. and Kuttan, R. (2000). Effect of Picrorrhiza kurroa extract on transplanted tumours and chemical carcinogenesis in mice. J. Ethnopharmacol. 71, 261-266 https://doi.org/10.1016/S0378-8741(00)00168-9
  15. Kamada, T., Hata, J., Kusunoki, H., Ito, M., Tanaka, S., Kawamura, Y., Chayama, K. and Haruma, K. Eradication of Helicobacter pylori increases the incidence of hyperlipidaemia and obesity in peptic ulcer patients. Dig. Liver Dis. 37, 39- 43
  16. Ko, Y.J., Wu, Y.W. and Lin, W.C. (2004). Hypolipidemic effect of Glycine tomentella root extract in hamsters. Am. J. Chin. Med. 32, 57-63 https://doi.org/10.1142/S0192415X04001783
  17. Lal, J.J., Sreeranjit Kumar, C.V., Suresh, M.V., Indira, M. and Vijayammal, P.L. (1998). Effect of in utero exposure of Toddy (coconut palm wine) on liver function and lipid metabolism in rat fetuses. Plant Foods Hum. Nutr. 52, 209-219 https://doi.org/10.1023/A:1008053405509
  18. Le, P.M., Benhaddou-Andaloussi, A., Elimadi, A., Settaf, A., Cherrah, Y. and Haddad, P.S. The petroleum ether extract of Nigella sativa exerts lipid-lowering and insulinsensitizing actions in the rat. J. Ethnopharmacol. 94, 251-259
  19. Lee, H.S., Ahn, H.C. and Ku, S.K. (2006a). Hypolipemic effect of water extracts of Picrorrhiza rhizoma in PX-407 induced hyperlipemic ICR mouse model with hepatoprotective effects: A prevention study. J. Ethnopharmacol. 105, 380-386 https://doi.org/10.1016/j.jep.2005.11.010
  20. Lee, H.S., Yoo, C.B. and Ku, S.K. (2006b). Hypolipemic effect of water extracts of Picrorrhiza rhizoma in high fat diet treated mouse. Fitoterapia, 77, 579-584 https://doi.org/10.1016/j.fitote.2006.09.004
  21. Mehrotra, R., Rawat, S., Kulshreshtha, D.K., Patnaik, G.K. and Dhawan, B.N. (1990). In vitro studies on the effect of certain natural products against hepatitis B virus. Indian J. Med. Res. 92, 133-138
  22. Milionis, H.J., Kakafika, A.I., Tsouli, S.G., Athyros, V.G., Bairaktari, E.T., Seferiadis, K.I. and Elisaf, M.S. (2004). Effects of statin treatment on uric acid homeostasis in patients with primary hyperlipidemia. Am. Heart J. 148, 635-640 https://doi.org/10.1016/j.ahj.2004.04.005
  23. Morishita, S., Saito, T., Mishima, Y., Mizutani, A., Hirai, Y., Koyama, S. and Kawakami, M. (1986) Strains and species differences in experimental hyperlipidemia. Nippon Yakurigaku Zasshi 87, 259-264 https://doi.org/10.1254/fpj.87.259
  24. Movahedian, A., Ghannadi, A., Sadeghi, H., Gharavi, M. and Azarpajhoh, S. (2004). Study of leek (Allium porrum. L) extract on cholesterol plasma levels in hyperlipidemic animals. Asia Pac. J. Clin. Nutr. 13, S103
  25. Mukai, M., Ozasa, K., Hayashi, K. and Kawai, K. (2002). Various S-GOT/S-GPT ratios in nonviral liver disorders and related physicalconditions and life-style. Dig. Dis. Sci. 47, 549-555 https://doi.org/10.1023/A:1017959801493
  26. Neaton, J.D., Kuller, L.H., Wentworth, D. and Borhani, N.O. (1984). Total and cardiovascular mortality in relation to cigarette smoking, serum cholesterol concentration and diastolic blood pressure among black and white males followed up for five years. Am. Heart J. 108, 759-769 https://doi.org/10.1016/0002-8703(84)90669-0
  27. Olsson, B., Bohlooly-Y, M., Fitzgerald, S.M., Frick, F., Ljungberg, A., Ahren, B., Tornell, J., Bergstrom, G. and Oscarsson, J. (2005). Bovine growth hormone transgenic mice are resistant to diet-induced obesity but develop hyperphagia, dyslipidemia, and diabetes on a high-fat diet. Endocrinology 146, 920-930 https://doi.org/10.1210/en.2004-1232
  28. Pari, L. and Amarnath Satheesh, M.. (2004). Antidiabetic effect of Boerhavia diffusa: effect on serum and tissue lipids in experimental diabetes. J. Med. Food 7, 472-476 https://doi.org/10.1089/jmf.2004.7.472
  29. Park, K.J., Kim, H.Y., Chang, B.J. and Lee, H.H. (2004). Ameliorative effects of soy 11S protein on liver damage and hyperlipidemia in alcohol-fed rats. Biol. Pharm. Bull. 27, 1636-1641 https://doi.org/10.1248/bpb.27.1636
  30. Patil, U.K., Saraf, S. And Dixit, V.K. (2004). Hypolipidemic activity of seeds of Cassia tora Linn. J. Ethnopharmacol. 90, 249-252 https://doi.org/10.1016/j.jep.2003.10.007
  31. Pedrosa, R.C., Meyre-Silva, C., Cechinel-Filho, V., Benassi, J.C., Oliveira, L.F., Zancanaro, V., Dal Magro, J. and Yunes, R.A. (2002). Hypolipidaemic activity of methanol extract of Aleurites moluccana. Phytother. Res. 16, 765- 768 https://doi.org/10.1002/ptr.1046
  32. Pirat, B., Korkmaz, M.E., Eroglu, S., Tayfun, E., Yildirir, A., Ulucam, M., Ozin, B. and Muderrisoglu, H. (2004). The effects of simvastatin combined with different antioxidant vitamin regimens on serum lipid profile in patients with low HDL cholesterol levels. Anadolu Kardiyol. Derg. 4, 318-322
  33. Regulska-Ilow, B., Biernat, J., Grajeta, H., Ilow, R. and Drzewicka, M. (2004). Influence of bioflavonoids from the radix extract of Scutellaria baicalensis on the level of serum lipids, and the development of laboratory rats fed with fresh and oxidized fats. Nahrung 48, 123-128 https://doi.org/10.1002/food.200300382
  34. Senanayake, G.V., Maruyama, M., Shibuya, K., Sakono, M., Fukuda, N., Morishita, T., Yukizaki, C., Kawano, M. and Ohta, H. (2004). The effects of bitter melon (Momordica charantia) on serum and liver triglyceride levels in rats. J. Ethnopharmacol. 91, 257-262 https://doi.org/10.1016/j.jep.2003.12.026
  35. Senthil Kumar, S.H., Anandan, R., Devaki, T. and Santhosh Kumar, M. (2001). Cardioprotective effects of Picrorrhiza kurroa against isoproterenol-induced myocardial stress in rats. Fitoterapia 72, 402-405 https://doi.org/10.1016/S0367-326X(01)00264-7
  36. Shukla, R., Gupta, S., Gambhir, J.K., Prabhu, K.M. and Murthy, P.S. (2004). Antioxidant effect of aqueous extract of the bark of Ficus bengalensis in hypercholesterolaemic rabbits. J. Ethnopharmacol. 92, 47-51 https://doi.org/10.1016/j.jep.2004.01.020
  37. Steinmetz, E.F., Buckley, C., Shames, M.L., Ennis, T.L., Vanvickle-Chavez, S.J., Mao, D., Goeddel, L.A, Hawkins, C.J. and Thompson, R.W. (2005). Treatment with simvastatin suppresses the development of experimental abdominal aortic aneurysms in normal and hypercholesterolemic mice. Ann. Surg. 41, 92-101
  38. Tan, B.K., Tan, C.H. and Pushparaj, P.N. (2005). Anti-diabetic activity of the semi-purified fractions of Averrhoa bilimbi in high fat diet fed-streptozotocin-induced diabetic rats. Life Sci. 76, 2827-2839 https://doi.org/10.1016/j.lfs.2004.10.051
  39. Vickers, S., Duncan, C.A., Vyas, K.P., Kari, P.H., Arison, B., Prakash, S.R., Ramjit, H.G., Pitzenberger, S.M., Stokker, G. and Duggan, D.E. (1990). In vitro and in vivo biotransformation of simvastatin, an inhibitor of HMG CoA reductase. Drug Metab. Dispos. 18, 476-483
  40. Yamashita, J. and Hayashi, S. (1990). The effect of dietary protein source on plasma cholesterol level and fecal steroid excretion in obese mice. J. Nutr. Sci. Vitaminol. (Tokyo), 36, 545-558 https://doi.org/10.3177/jnsv.36.545
  41. Yokode, M., Hammer, R.E., Ishibashi, S., Brown, M.S. and Goldstein, J.L. (1990). Diet-induced hypercholesterolemia in mice: prevention by overexpression of LDL receptors. Science, 50, 1273-1275
  42. Yokozawa, T., Ishida, A., Cho, E.J. and Nakagawa, T. (2003). The effects of Coptidis Rhizoma extract on a hypercholesterolemic animal model. Phytomedicine 10, 17-22 https://doi.org/10.1078/094471103321648610
  43. Yu, Y.M., Chang, W.C., Liu, C.S. and Tsai, C.M. (2004). Effect of young barley leaf extract and adlay on plasma lipids and LDL oxidation in hyperlipidemic smokers. Biol. Pharm. Bull. 27, 802-805 https://doi.org/10.1248/bpb.27.802
  44. Zdrenghea, D., Gligor, E., Ossian, V. and Pop, D. (2004). The effect of simvastatin associated with ranitidine and alcohol upon serum lipids. Rom. J. Intern. Med. 42, 143- 148
  45. Zhu, H.M. and Zhu, B.D. (2004). Experimental study on preventive effect of Radix Paeoniae Rubra to restenosis after carotid balloon injury in high fat-diet rabbits. Zhongguo Zhong Xi Yi Jie He Za Zhi, 24, 538-540

피인용 문헌

  1. Micronucleus Test of Picrorrhiza Rhizoma Aqueous Extract in Bone Marrow Cells of Male ICR Mice vol.27, pp.2, 2011, https://doi.org/10.5487/TR.2011.27.2.119
  2. Effect of Picrorrhizae Rhizoma Aqueous Extracts on Paw Chronic Inflammation In Mice vol.36, pp.2, 2015, https://doi.org/10.13048/jkm.15011
  3. Effects of Picrorrhiza Rhizoma on Acute Inflammation in Mice vol.16, pp.2, 2008, https://doi.org/10.4062/biomolther.2008.16.2.137
  4. Effect of Picrorrhiza Rhizoma on Dinitrofluorobenzene-induced Contact Dermatitis (Type I allergy) vol.16, pp.3, 2008, https://doi.org/10.4062/biomolther.2008.16.3.237