Journal of Life Science (생명과학회지)

Korean Society of Life Science (한국생명과학회)
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Adenocarcinoma of Meibomian Glands and Moll Glands in the Eyelid of Canine

개의 안검에 존재하는 내검판선 및 외검판선에서 발생한 선암종

  • Yuan, Dong-wei (Department of Pathology, College of Veterinary Medicine, Kyungpook NationalUniversity) ;
  • Goo, Moon-Jung (Department of Pathology, College of Veterinary Medicine, Kyungpook NationalUniversity) ;
  • Yang, Hai-jie (Department of Pathology, College of Veterinary Medicine, Kyungpook NationalUniversity) ;
  • Hong, Il-Hwa (Department of Pathology, College of Veterinary Medicine, Kyungpook NationalUniversity) ;
  • Ki, Mi-Ran (Department of Pathology, College of Veterinary Medicine, Kyungpook NationalUniversity) ;
  • Park, Jin-Kyu (Department of Pathology, College of Veterinary Medicine, Kyungpook NationalUniversity) ;
  • Lee, Hye-Rim (Department of Pathology, College of Veterinary Medicine, Kyungpook NationalUniversity) ;
  • Yoo, Sung-Eun (Korea Research Institute of Chemical Technology) ;
  • Jeong, Kyu-Shik (Department of Pathology, College of Veterinary Medicine, Kyungpook NationalUniversity)
  • 위엔동웨이 (경북대학교 수의과대학 병리학교실) ;
  • 구문정 (경북대학교 수의과대학 병리학교실) ;
  • 양해걸 (경북대학교 수의과대학 병리학교실) ;
  • 홍일화 (경북대학교 수의과대학 병리학교실) ;
  • 기미란 (경북대학교 수의과대학 병리학교실) ;
  • 박진규 (경북대학교 수의과대학 병리학교실) ;
  • 이혜림 (경북대학교 수의과대학 병리학교실) ;
  • 유성은 (한국화학연구원) ;
  • 정규식 (경북대학교 수의과대학 병리학교실)
  • Published : 2008.03.31
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Abstract

A 4-year-old female beagle with progressive exophthalmos and which had a neoplastic mass with diameter of 1.4 cm in the left lower ocular adnexa. Histologically, the mass was composed of hyper-plastic lobules and tubular structures separated by fibrous septum. The well differentiated sebaceous gland forming various sized lobules, and infiltration of mast cells and mononuclear inflammatory cells were observed. Apical decapitation secretion of these tubular structures with basophilic materials in their lumen showed mild sebaceous gland metaplasia. Immunohistochemical studying, cell groups were positive in ${\alpha}-SMA$ and vimentin. The primary tumor was diagnosed as adenocarcinoma originated from moll gland and meibomian gland of the eyelid, and the infiltrating intraocular neoplasm was diagnosed as a malignant mixed tumor.

본 증례는 4년령의 암컷 비글종에서 발생한 것으로 점진적인 안구돌출증을 비롯하여 왼쪽 하안구 부속기에 발생한 직경 1.4 cm 의 종양을 가지고 있었다. 종양의 병리조직학적 검경에서 증생된 종양 세포들이 소엽 및 섬유성 격벽으로 구분되는 관통상의 구조를 나타내고 있었다. 잘 분화된 피지선은 다양한 크기의 소엽을 형성하고 있으며 비만세포 및 단핵 염증세포의 침윤이 관찰되었다. 관강 내에는 이러한 관성구조의 정점부위에서 탈락되어 나온 호염성 불질이 관찰되었으며 일부 관성구조는 경도의 화생을 나타내고 있었다. 조직면역염색에서 세포집단은 ${\alpha}-SMA$와 vimentin에 양성 반응을 나타내었다. 따라서 본 원발성 종양은 안검에서 발생한 내검판선 및 외검판선 유래의 선암종으로 진단되었으며 침윤되고 있는 안구내 종양은 악성 혼합종으로 진단되었다.

Keywords

References

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