대한한방소아과학회지 (The Journal of Pediatrics of Korean Medicine)
- 제22권3호
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- Pages.105-137
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- 2008
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- 1226-8038(pISSN)
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- 2287-9463(eISSN)
구풍제습탕(驅風除濕湯)이 DNCB로 유도된 NC/Nga mice의 아토피 피부염에 미치는 영향
Effect of Gupoongjeseuptang (GPJST) on DNCB (dinitrochlorobenzene)-induced Atopic Dermatitis-like Model NC/Nga Mice
- 윤재은 (대전대학교 한의과대학 소아과학교실) ;
- 김윤희 (대전대학교 한의과대학 소아과학교실) ;
- 한재경 (대전대학교 한의과대학 소아과학교실) ;
- 김윤희 (대전대학교 한의과대학 소아과학교실)
- Yoon, Jae-Eun (Department of Pediatrics, College of Oriental Medicine, Daejeon University) ;
- Kim, Yun-Hee (Department of Pediatrics, College of Oriental Medicine, Daejeon University) ;
- Han, Jae-Kyung (Department of Pediatrics, College of Oriental Medicine, Daejeon University) ;
- Kim, Yun-Hee (Department of Pediatrics, College of Oriental Medicine, Daejeon University)
- 발행 : 2008.12.31
초록
Objectives : The purpose of this study is to investigate the effect of Gupoongjeseuptang (GPJST) on atopic dermatitis by in vivo experiment using NC/Nga atopic dermatitis mouse, which has histological and clinical similarities to the atopic dermatitis of human. Methods : To investigate the effect of GPJST on atopic dermatifis, we evaluated atopic dermatitis-like skin lesions by clinical skin index and analyzed immunological parameters in peripheral blood mononuclear cells (PBMCs), splenocytes, draining lymph node (DLN) and performed skin histology in ears and dorsal skin of atopic dermatitis-like skin NC/Nga mouse in vivo. Results : In vivo, clinical skin severity score were significantly lower in GPJST group than control group. IgE, IL-6,