Korean Journal of Oriental Medicine (한국한의학연구원논문집)
- Volume 14 Issue 3
- /
- Pages.41-47
- /
- 2008
- /
- 1229-3377(pISSN)
Analysis of Studies on Ssanghwa-tang for Establishment of Evidence Based Medicine
EBM 구축을 위한 쌍화탕의 실험 연구 문헌 분석
-
Lee, Jun-Kyoung
(Korea Institute of Oriental Medicine) ;
- Lee, Nam-Hun (Korea Institute of Oriental Medicine) ;
-
Ha, Hye-Kyoung
(Korea Institute of Oriental Medicine) ;
-
Lee, Ho-Young
(Korea Institute of Oriental Medicine) ;
-
Seo, Chang-Sub
(Korea Institute of Oriental Medicine) ;
- Jung, Da-Young (Korea Institute of Oriental Medicine) ;
- Lee, Jin-Ah (Korea Institute of Oriental Medicine) ;
-
Shin, Hyun-Kyu
(Korea Institute of Oriental Medicine)
-
이준경
(한국한의학연구원) ;
- 이남헌 (한국한의학연구원) ;
-
하혜경
(한국한의학연구원) ;
-
이호영
(한국한의학연구원) ;
-
서창섭
(한국한의학연구원) ;
- 정다영 (한국한의학연구원) ;
- 이진아 (한국한의학연구원) ;
-
신현규
(한국한의학연구원)
- Published : 2008.12.30
Abstract
Objective : The purpose of this report was to provide the information about activity and safety of Ssanghwa-tang by analyzing domestic papers and theses about Ssanghwa-tang. Methods : Domestic papers and theses related to Ssanghwa-tang were reviewed and analyzed. These papers were then classified by year, experimental method, and activity subject. Results : The following result s were obtained in this study. 1. The study of Ssanghwa-tang started from 1981 and continued steadily 1990s and it was decreased 2000s. 2. The paper of Ssanghwatang was entire domestic paper, 20 volumes. 3. In classified by experimental method and animal of Ssanghwa-tang paper, more than a half study used rat in vivo experiment. Furthermore clinical experiments were performed about anti-fatigue effect of Ssanghwa-tang and Ssanghwatang was proved a safety herbal medicine in acute toxicity experiment. 4. Decursin, glycyrrhizin, paeoniflorin were determined in Ssanghwa-tang by using HPLC analysis. 5. As these studies were classified by subject, papers related to anti-fatigue effect were most abundant by 7 papers. Besides there were several papers related to liver funtion, anti-inflammatory, alleviation, smooth muscle relaxation effect and so on. 6. According to experimental data, it is supported that Ssanghwa-tang was safety herbal medicine and it has a several activity about anti-fatigue, anti-inflammatory, alleviation, smooth muscle relaxation. Conclusion : Many study of basic science experiments and clinical experiments were performed and reported on Ssanghwa-tang in domestic journal. Ssanghwa-tang is being used in various ways associating with anti-fatigue, anti-inflammatory, alleviation and smooth muscle relaxation. furthermore Ssanghwatang was proved a safety herbal medicine in acute toxicity experiment. However, studies on randomized controlled trials of Ssanghwatang need to be completed at the clinical level.
Keywords
- Ssanghwa-tang;
- Evidence Based Medicine (EBM);
- Safety herbal medicine;
- Experimental research;
- Anti-fatigue