Animal cells and systems

The Korean Society for Integrative Biology (한국통합생물학회)
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The Effect of Idesolide on Hippocampus-dependent Recognition Memory

  • Lee, Hye-Ryeon (National Creative Research Initiative Center for Memory, Department of Biological Sciences, College of Natural Sciences, Seoul National University) ;
  • Choi, Jun-Hyeok (National Creative Research Initiative Center for Memory, Department of Biological Sciences, College of Natural Sciences, Seoul National University) ;
  • Lee, Nuribalhae (National Creative Research Initiative Center for Memory, Department of Biological Sciences, College of Natural Sciences, Seoul National University) ;
  • Kim, Seung-Hyun (College of Pharmacy, Seoul National University) ;
  • Kim, Young-Choong (College of Pharmacy, Seoul National University) ;
  • Kaang, Bong-Kiun (National Creative Research Initiative Center for Memory, Department of Biological Sciences, College of Natural Sciences, Seoul National University)
  • Published : 2008.03.31
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Abstract

Finding a way to strengthen human cognitive functions, such as learning and memory, has been of great concern since the moment people realized that these functions can be affected and even altered by certain chemicals. Since then, plenty of endeavors have been made to look for safe ways of improving cognitive performances without adverse side-effects. Unfortunately, most of these efforts have turned out to be unsuccessful until now. In this study, we examine the effect of a natural compound, idesolide, on hippocampus-dependent recognition memory. We demonstrate that idesolide is effective in the enhancement of recognition memory, as measured by a novel object recognition task. Thus, idesolide might serve as a novel therapeutic medication for the treatment of memoryrelated brain anomalies such as mild cognitive impairment(MCI) and Alzheimer's disease.

Keywords

References

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