Advances in Traditional Medicine

Kyung Hee Oriental Medicine Research Center (경희대학교 융합한의과학연구소)
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Anti-inflammatory and anti-nociceptive effects of extract of Astragalus membranaceous

  • Kim, Young-Ock (Ginseng & Medicinal Crops Division, National Institute of Crop Science, Rural Development Administration) ;
  • Kim, Su-Kang (Kohwang Medical Research Institute, Department of Pharmacology, School of Medicine, Kyung Hee University) ;
  • Cho, Ah-Rang (Kohwang Medical Research Institute, Department of Pharmacology, School of Medicine, Kyung Hee University) ;
  • Chung, Joo-Ho (Kohwang Medical Research Institute, Department of Pharmacology, School of Medicine, Kyung Hee University)
  • Published : 2008.02.29
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Abstract

The root of Astragalus membranaceous (AM) has been used to treat edema and arthritis in the traditional Korean medicine. To elucidate the anti-inflammatory and anti-nociceptive effects of ethanol extract of AM, the carrageenan-induced paw edema using a plethysmometer and thermal hypersensitivity using the plantar test were measured. Ibuprofen was used as a control drug. Pretreatment with AM (400 mg/kg p.o.) significantly reduced paw edema, compared to the carrageenan-treated rats. In the plantar test, the thermal withdrawal latency in AM-treated group was significantly increased than the carrageenan-treated group. The results indicate that AM could have be the anti-inflammatory and anti-nociceptive properties.

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References

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