Advances in Traditional Medicine

  • 제7권5호
  • /
  • Pages.527-533
  • /
  • 2008
  • /
  • 2662-4052(pISSN)
  • /
  • 2662-4060(eISSN)
경희대학교 융합한의과학연구소 (Kyung Hee Oriental Medicine Research Center)
권호 표지
DOI QR코드

DOI QR Code

Analgesic and anti-inflammatory effect of the aqueous extract of root of Angelica Dahurica

  • Choi, In-Ho (Department of Rehabilitation Medicine, College of Oriental Medicine, Kyungwon University) ;
  • Lim, Hyung-Ho (Department of Rehabilitation Medicine, College of Oriental Medicine, Kyungwon University) ;
  • Song, Yun-Kyung (Department of Rehabilitation Medicine, College of Oriental Medicine, Kyungwon University) ;
  • Lee, Jin-Woo (Kohwang Medical Research Institute, Department of Physiology, College of Medicine, Kyung Hee University) ;
  • Kim, Young-Sick (Kohwang Medical Research Institute, Department of Physiology, College of Medicine, Kyung Hee University) ;
  • Ko, Il-Gyu (Kohwang Medical Research Institute, Department of Physiology, College of Medicine, Kyung Hee University) ;
  • Kim, Ki-Jeong (Kohwang Medical Research Institute, Department of Physiology, College of Medicine, Kyung Hee University) ;
  • Shin, Mal-Soon (Kohwang Medical Research Institute, Department of Physiology, College of Medicine, Kyung Hee University) ;
  • Kim, Khae-Hawn (Department of Urology, Gil Medical Center, Gachon University of Medicine and Science) ;
  • Kim, Chang-Ju (Kohwang Medical Research Institute, Department of Physiology, College of Medicine, Kyung Hee University)
  • 발행 : 2008.02.29
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Angelica dahurica (Umbelliferae) grows in China, Japan, Russia, and Korea. The root of Angelica dahurica has been used as a traditional folk medicine to treat headache and toothache. In this study, the effects of the aqueous extract of Angelica dahurica on acetic acid-induced abdominal pain, carrageenan-induced edema, and thermal hyperalgesia were investigated using mice and rats. The present results showed that the aqueous extract of Angelica dahurica inhibited acetic acidinduced abdominal pain in mice and reduced carrageen-induced edema in rats. The present study showed that the aqueous extract of Angelica dahurica possesses anti-inflammatory and analgesic effects.

키워드

참고문헌

  1. Ban HS, Lim SS, Suzuki K, Jung SH, Lee S, Lee YS, Shin KH, Ohuchi K. (2003) Inhibitory effects of furanocoumarins isolated from the roots of Angelica dahuricaon prostaglandin E2 production. Planta Med. 69, 408-412 https://doi.org/10.1055/s-2003-39702
  2. Chen YF, Tsai HY, Wu TS. (1995) Anti-inflammatory and analgesic activities from roots of Angelica pubescens. Planta Med. 61, 2-8 https://doi.org/10.1055/s-2006-957987
  3. Cooper BY, Vierck Jr CJ, Yeomans DC. (1986) Selective reduction of second pain sensations by systemic morphine in humans. Pain 24, 93-116 https://doi.org/10.1016/0304-3959(86)90030-8
  4. Di Rosa M, Giroud JP, Willoughby DA. (1971) Studies on the mediators of the acute inflammatory response induced in rats in different sites by carrageenan and turpentine. J. Pathol. 104, 15-29 https://doi.org/10.1002/path.1711040103
  5. Franzotti EM, Santos CV, Rodrigues HM, Mourao RH, Andrade MR, Antoniolli AR. (2000) Antiinflammatory, analgesic activity and acute toxicity of Sida cordifolia L. (Malva-branca). J. Ethnopharmacol. 72, 273-277 https://doi.org/10.1016/S0378-8741(00)00205-1
  6. Griffiths RJ. (1999) Prostaglandins and inflammation. In: Inflammation: Basic Principle and Clinical Correlates, 3rd ed. Gallin JI, Snyderman R. p. 349- 360, Lippincott Williams and Wilkins Press, Philadelphia
  7. Hargreaves K, Dubner R, Brown F, Flores C, Joris J. (1988) A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain 32, 77-88 https://doi.org/10.1016/0304-3959(88)90026-7
  8. Hudson JB, Graham EA, Harris L, Ashwood-Smith MJ. (1993) The unusual UVA-dependent antiviral properties of the furoisocoumarin, coriandrin. Photochem. Photobiol. 57, 491-496 https://doi.org/10.1111/j.1751-1097.1993.tb02324.x
  9. Kim DK, Lim JP, Yang JH, Eom DO, Eun JS, Leem KH. (2002) Acetylcholinesterase inhibitors from the roots of Angelica dahurica. Arch. Pharm. Res. 25, 856- 859
  10. Kim SH, Kang SS, Kim CM. (1992) Coumarin glycosides from the roots of Angelica dahurica. Arch. Pharm. Res. 15, 73-77
  11. Kimura Y, Ohminami H, Arichi H, Okuda H, Baba K, Kozawa M. (1982) Effects of various coumarins from roots of Angelica dahurica on actions of adrenaline, ACTH and insulin in fat cells. Planta Med. 45, 183-187 https://doi.org/10.1055/s-2007-971370
  12. Kimura Y, Okuda H. (1997) Histamine-release effectors from Angelica dahurica var. dahurica root. J. Nat. Prod. 60, 249-251 https://doi.org/10.1021/np960407a
  13. Kofinas C, Chinou I, Loukis A, Harvala C, Roussakis C, Maillard M, Hostettmann K. (1998) Cytotoxic coumarins from the aerial parts of Tordylium apulum and their effects on a non-small-cell bronchial carcinoma line. Planta Med. 64, 174-176
  14. Kuzel TM, Roenigk HH, Samuelson E, Rosen ST. (1992) Suppression of anti-interferon alpha-2a antibody formation in patients with mycosis fungoides by exposure to long-wave UV radiation in the A range and methosalen ingestion. J. Natl. Cancer Inst. 84, 119-121 https://doi.org/10.1093/jnci/84.2.119
  15. Kwon YS, Kobayashi A, Kajiyama SI, Kawazu K, Kanzaki H, Kim CM. (1997) Antimicrobial constituents of Angelica dahurica. Phytochemistry 44, 887-889 https://doi.org/10.1016/S0031-9422(96)00634-6
  16. Light A, Perl E. (2003) Unmyelinated afferent fibers are not only for pain anymore. J. Comp. Neurol. 461, 137-139 https://doi.org/10.1002/cne.10691
  17. Masferrer JL, Zweifel BS, Manning PT, Hauser SD, Leahy KM, Smith WG, Isakson PC, Seibert K. (1994) Selective inhibition of inducible cyclooxygenase 2 in vivo is anti-inflammatory and nonulcerogenic. Proc. Natl. Acad. Sci. U.S.A. 91, 3228-3232 https://doi.org/10.1073/pnas.91.8.3228
  18. Panthong A, Kanjanapothi D, Taesotikul T, Phankummoon A, Panthong K, Reutrakul V. (2004) Anti-inflammatory activity of methanolic extracts from Ventilago harmandiana Pierre. J. Ethnopharmacol. 91, 237-242 https://doi.org/10.1016/j.jep.2003.12.025
  19. Ryu SY, Kuo NY, Choi HS, Ryu H, Kim TS, Kim KM. (2001) Cnidicin, a coumarin from the root of Angelica koreana, inhibits the degranulation of mast cell and the NO generation in RAW 264.7 cells. Planta Med. 67, 172-174 https://doi.org/10.1055/s-2001-11509
  20. Saiki Y, Morinaga K, Okegawa O, Sakai S, Amaya Y. (1971) On the coumarins of the roots of Angelica dahurica Benth. Et Hook. Yakugaku Zasshi 91, 1313- 1317
  21. Sluka KA, Chandran P. (2002) Enhanced reduction in hyperalgesia by combined administration of clonidine and TENS. Pain 100, 183-190 https://doi.org/10.1016/S0304-3959(02)00294-4
  22. Vierck Jr CJ, Cannon RL, Fry G, Maixner WL. (1997) Characteristics of temporal summation of second pain sensations elicited by brief contact of glabrous skin by a preheated thermode. J. Neurophysiol. 78, 992-1002
  23. Wang NH, Yoshizaki K, Baba K. (2001) Seven new bifuranocoumarins, dahuribirin A-G, from Japanese Bai Zhi. Chem. Pharm. Bull. 49, 1085-1088 https://doi.org/10.1248/cpb.49.1085