Molecular & Cellular Toxicology

The Korean Society of Toxicogenomics and Toxicoproteomics (대한독성유전 단백체학회)
권호 표지

Lack of Association between Serotonin Transporter Promoter Gene Polymorphism and Citalopram Response in Major Depressive Disorder

  • Kang, Rhee-Hun (Department of psychiatry, College of Medicine, Korea University) ;
  • Choi, Myoung-Jin (Clinical Research Center for Depression, Korea University) ;
  • Chang, Hun-Soo (Clinical Research Center for Depression, Korea University) ;
  • Hahn, Sang-Woo (Department of psychiatry, College of Medicine, Soonchunhyang University) ;
  • Lee, Hwa-Young (Department of psychiatry, College of Medicine, Korea University) ;
  • Paik, Jong-Woo (Department of Psychiatry, College of medicine, Kyunghee university) ;
  • Lim, Se-Won (Department of psychiatry, College of medicine, Sungkyunkwan University Kangbuk Samsung Hospital, School of Medicine) ;
  • Oh, Kang-Seob (Department of psychiatry, College of medicine, Sungkyunkwan University Kangbuk Samsung Hospital, School of Medicine) ;
  • Jung, Han-Yong (Department of psychiatry, College of Medicine, Soonchunhyang University) ;
  • Lee, Min-Soo (Department of psychiatry, College of Medicine, Korea University)
  • Published : 2008.03.31
Download PDF
⟨ Previous Next ⟩

Abstract

The 5-HTT gene is a candidate gene for influencing the clinical response to antidepressant treatment. The purpose of this gene study was to determine the relationship between serotonin transporter gene polymorphism at the SLC6A4 and the response to citalopram in a Korean population with major depressive disorder (MDD). Citalopram was administered for 8 weeks to the 80 patients who completed this study. The severity of depression was assessed with the 21-item Hamilton Depression Rating scale, and the 5-HTTLPR genotypes in the patients were determined using the polymerase chain reaction. Our result did not showed significant differences in, allele, and carrier distribution between the normal group and MDD patients. This study suggest that polymorphism of the 5HTT gene was not associated with citalopram response to MDD in the Korean population.

Keywords

References

  1. Williams, R. B. Neurobiology, cellular and molecular biology, and psychosomatic medicine. Psychosom Med 56:308-315 (1994) https://doi.org/10.1097/00006842-199407000-00006
  2. Smeraldi, E. et al. Polymorphism within the promoter of the serotonin transporter gene and antidepressant efficacy of fluvoxamine. Mol Psychiatry 3:508-511 (1998) https://doi.org/10.1038/sj.mp.4000425
  3. Zanardi, R., Benedetti, F., Di Bella, D., Catalano, M. & Smeraldi, E. Efficacy of paroxetine in depression is influenced by a functional polymorphism within the promoter of the serotonin transporter gene. J Clin Psychopharmacol 20:105-107 (2000) https://doi.org/10.1097/00004714-200002000-00021
  4. Smits, K. M. et al. Influence of SERTPR and STin2 in the serotonin transporter gene on the effect of selective serotonin reuptake inhibitors in depression: a systematic review. Mol Psychiatry 9:433-441 (2004) https://doi.org/10.1038/sj.mp.4001488
  5. Baumann, P. & Rochat, B. Comparative pharmacokinetics of selective serotonin reuptake inhibitors: a look behind the mirror. Int Clin Psychopharmacol 10: 15-21 (1995) https://doi.org/10.1097/00004850-199509000-00003
  6. Martin, R. M., Hilton, S. R., Kerry, S. M. & Richards, N. M. General practitioners' perceptions of the tolerability of antidepressant drugs: a comparison of selective serotonin reuptake inhibitors and tricyclic antidepressants. BMJ 314:646-651 (1997) https://doi.org/10.1136/bmj.314.7081.646
  7. Heils, A. et al. Allelic variation of human serotonin transporter gene expression. J Neurochem 66:2621-2624 (1996) https://doi.org/10.1046/j.1471-4159.1996.66062621.x
  8. Greenberg, B. D. et al. Genetic variation in the serotonin transporter promoter region affects serotonin uptake in human blood platelets. Am J Med Genet 88:83-87 (1999) https://doi.org/10.1002/(SICI)1096-8628(19990205)88:1<83::AID-AJMG15>3.0.CO;2-0
  9. Owens, M. J. & Nemeroff, C. B. Role of serotonin in the pathophysiology of depression: focus on the serotonin transporter. Clin Chem 40:288-295 (1994)
  10. Rothman, K. J. No adjustments are needed for mutiple comparisons. Epidemiology 1:43-46 (1990) https://doi.org/10.1097/00001648-199001000-00010
  11. Buchner, A., Faul, F. & Erdfelder, E. G.Power: A priori, post-hoc, and compromise power analyses for the Macintosh (Version 2.1.1) [Computer Program]. Trier, University of Trier (1996)
  12. Ramamoorthy, S. et al. Antidepressant-and cocainesensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization. Proc Natl Acad Sci USA 90:2542-2546 (1993)
  13. Lesch, K. P. et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 29:1527-1531 (1996)
  14. Kim, D. K. et al. Serotonin transporter gene polymorphism and antidepressant response. Neuroreport 11: 215-219 (2000) https://doi.org/10.1097/00001756-200001170-00042
  15. Yoshida, K. et al. Influence of the serotonin transporter gene-linked polymorphic region on the antidepressant response to fluvoxamine in Japanese depressed patients. Prog Neuropsychopharmacol Biol Psychiatry 26:383-386 (2002) https://doi.org/10.1016/S0278-5846(01)00287-1
  16. Arias, B., Catalan, R., Gasto, C., Gutierrez, B. & Fananas, L. 5-HTTLPR polymorphism of the serotonin transporter gene predicts non-remission in major depression patients treated with citalopram in a 12-weeks follow up study. J Clin Psychopharmacol 23:563-567 (2003) https://doi.org/10.1097/01.jcp.0000095350.32154.73
  17. Kim, H. et al. Monoamine transporter gene polymorphisms and antidepressant response in Koreans with late-life depression. JAMA 296:1609-1618 (2006) https://doi.org/10.1001/jama.296.13.1609
  18. Kim, J. W. Association study and the population admixture. Winter Workshop on Human Neurobehavioral Genetics in the 21st Century. Seoul. Korean Society of Biological Psychiatry (2003)