Schizophrenia and Immunological Abnormalities

정신분열병과 면역학적 이상

  • Jung, Hee Yeon (Department of Neuropsychiatry, Seoul National University, Boramae Medical Center) ;
  • Kim, Yong-Sik (Department of Neuropsychiatry, Seoul National University Hospital)
  • 정희연 (서울대학교 보라매병원 신경정신과) ;
  • 김용식 (서울대학교병원 신경정신과)
  • Published : 2008.08.31

Abstract

There have been vast amount studies regarding immunologic dysregulation in schizophrenia. The mechanism of immune pathogenesis in schizophrenia still is unclear, even though various immune dysfunction have been reported. We endeavored to report on two major hypothesis on immunologic dysregulation in schizophrenia, the infection hypothesis and autoimmune hypothesis. We went on to focus on the autoimmune hypothesis, which has received the most attention over the years. We explored the accumulated data and the rational behind the autoimmune hypothesis and the implications of the autoimmune hypothesis for future research in the pathogenesis of schizophrenia.

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