생물정신의학 (Korean Journal of Biological Psychiatry)
- 제15권3호
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- Pages.152-174
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- 2008
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- 1225-8709(pISSN)
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- 2005-7571(eISSN)
정신분열병과 면역학적 이상
Schizophrenia and Immunological Abnormalities
- Jung, Hee Yeon (Department of Neuropsychiatry, Seoul National University, Boramae Medical Center) ;
- Kim, Yong-Sik (Department of Neuropsychiatry, Seoul National University Hospital)
- 발행 : 2008.08.31
초록
There have been vast amount studies regarding immunologic dysregulation in schizophrenia. The mechanism of immune pathogenesis in schizophrenia still is unclear, even though various immune dysfunction have been reported. We endeavored to report on two major hypothesis on immunologic dysregulation in schizophrenia, the infection hypothesis and autoimmune hypothesis. We went on to focus on the autoimmune hypothesis, which has received the most attention over the years. We explored the accumulated data and the rational behind the autoimmune hypothesis and the implications of the autoimmune hypothesis for future research in the pathogenesis of schizophrenia.